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Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation.

Moorman HR, Poschel D, Klement JD, Lu C, Redd PS, Liu K. Moorman HR, et al. Among authors: klement jd. Cancers (Basel). 2020 Nov 15;12(11):3379. doi: 10.3390/cancers12113379. Cancers (Basel). 2020. PMID: 33203146 Free PMC article. Review.

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An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.

Klement JD, Paschall AV, Redd PS, Ibrahim ML, Lu C, Yang D, Celis E, Abrams SI, Ozato K, Liu K. Klement JD, et al. J Clin Invest. 2018 Dec 3;128(12):5549-5560. doi: 10.1172/JCI123360. Epub 2018 Nov 5. J Clin Invest. 2018. PMID: 30395540 Free PMC article.

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Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells.

Smith AD, Lu C, Payne D, Paschall AV, Klement JD, Redd PS, Ibrahim ML, Yang D, Han Q, Liu Z, Shi H, Hartney TJ, Nayak-Kapoor A, Liu K. Smith AD, et al. Among authors: klement jd. Cancer Res. 2020 Aug 1;80(15):3145-3156. doi: 10.1158/0008-5472.CAN-19-3670. Epub 2020 Jun 17. Cancer Res. 2020. PMID: 32554751 Free PMC article.

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Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.

Ibrahim ML, Klement JD, Lu C, Redd PS, Xiao W, Yang D, Browning DD, Savage NM, Buckhaults PJ, Morse HC 3rd, Liu K. Ibrahim ML, et al. Among authors: klement jd. Cell Rep. 2018 Dec 11;25(11):3036-3046.e6. doi: 10.1016/j.celrep.2018.11.050. Cell Rep. 2018. PMID: 30540937 Free PMC article.

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Clinical Scenario of the Metabolic Syndrome.

Brede S, Serfling G, Klement J, Schmid SM, Lehnert H. Brede S, et al. Among authors: klement j. Visc Med. 2016 Oct;32(5):336-341. doi: 10.1159/000449028. Epub 2016 Sep 19. Visc Med. 2016. PMID: 27921045 Free PMC article. Review.

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MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment.

Mudd TW Jr, Lu C, Klement JD, Liu K. Mudd TW Jr, et al. Among authors: klement jd. Cell Immunol. 2021 Feb;360:104260. doi: 10.1016/j.cellimm.2020.104260. Epub 2020 Dec 14. Cell Immunol. 2021. PMID: 33352466

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Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells.

Ibrahim ML, Lu C, Klement JD, Redd PS, Yang D, Smith AD, Liu K. Ibrahim ML, et al. Among authors: klement jd. Cancer Immunol Immunother. 2020 Nov;69(11):2233-2245. doi: 10.1007/s00262-020-02620-w. Epub 2020 Jun 1. Cancer Immunol Immunother. 2020. PMID: 32488308

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SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth.

Lu C, Klement JD, Yang D, Albers T, Lebedyeva IO, Waller JL, Liu K. Lu C, et al. Among authors: klement jd. Cancer Lett. 2020 Apr 28;476:87-96. doi: 10.1016/j.canlet.2020.02.004. Epub 2020 Feb 12. Cancer Lett. 2020. PMID: 32061753 Free PMC article.

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SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion.

Lu C, Yang D, Klement JD, Oh IK, Savage NM, Waller JL, Colby AH, Grinstaff MW, Oberlies NH, Pearce CJ, Xie Z, Kulp SK, Coss CC, Phelps MA, Albers T, Lebedyeva IO, Liu K. Lu C, et al. Among authors: klement jd. Cancer Immunol Res. 2019 Mar;7(3):414-427. doi: 10.1158/2326-6066.CIR-18-0126. Epub 2019 Jan 4. Cancer Immunol Res. 2019. PMID: 30610059 Free PMC article.

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Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways.

August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S. August A, et al. Among authors: klement j. J Neurochem. 2019 Dec;151(5):626-641. doi: 10.1111/jnc.14716. Epub 2019 Jun 6. J Neurochem. 2019. PMID: 31063592 Free article.

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