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Heartburn requiring frequent antacid use may indicate significant illness.
Robinson M, Earnest D, Rodriguez-Stanley S, Greenwood-Van Meerveld B, Jaffe P, Silver MT, Kleoudis CS, Wilson LE, Murdock RH. Robinson M, et al. Among authors: kleoudis cs. Arch Intern Med. 1998 Nov 23;158(21):2373-6. doi: 10.1001/archinte.158.21.2373. Arch Intern Med. 1998. PMID: 9827789
Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. North American Azathioprine Study Group.
Sandborn WJ, Tremaine WJ, Wolf DC, Targan SR, Sninsky CA, Sutherland LR, Hanauer SB, McDonald JW, Feagan BG, Fedorak RN, Isaacs KL, Pike MG, Mays DC, Lipsky JJ, Gordon S, Kleoudis CS, Murdock RH Jr. Sandborn WJ, et al. Among authors: kleoudis cs. Gastroenterology. 1999 Sep;117(3):527-35. doi: 10.1016/s0016-5085(99)70445-2. Gastroenterology. 1999. PMID: 10464128 Clinical Trial.
Managing heartburn at the 'base' of the GERD 'iceberg': effervescent ranitidine 150 mg b.d. provides faster and better heartburn relief than antacids.
Earnest D, Robinson M, Rodriguez-Stanley S, Ciociola AA, Jaffe P, Silver MT, Kleoudis CS, Murdock RH. Earnest D, et al. Among authors: kleoudis cs. Aliment Pharmacol Ther. 2000 Jul;14(7):911-8. doi: 10.1046/j.1365-2036.2000.00785.x. Aliment Pharmacol Ther. 2000. PMID: 10886047 Free article. Clinical Trial.