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Mitochondrial target of thiazolidinediones.

Colca JR, McDonald WG, Kletzien RF. Colca JR, et al. Among authors: kletzien rf. Diabetes Obes Metab. 2014 Nov;16(11):1048-54. doi: 10.1111/dom.12308. Epub 2014 May 22. Diabetes Obes Metab. 2014. PMID: 24774061 Review.

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Animal cell cycle.

Pardee AB, Dubrow R, Hamlin JL, Kletzien RF. Pardee AB, et al. Among authors: kletzien rf. Annu Rev Biochem. 1978;47:715-50. doi: 10.1146/annurev.bi.47.070178.003435. Annu Rev Biochem. 1978. PMID: 354504 Review. No abstract available.

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What has prevented the expansion of insulin sensitisers?

Colca JR, Kletzien RF. Colca JR, et al. Among authors: kletzien rf. Expert Opin Investig Drugs. 2006 Mar;15(3):205-10. doi: 10.1517/13543784.15.3.205. Expert Opin Investig Drugs. 2006. PMID: 16503758 Review.

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Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases.

Colca JR, Tanis SP, McDonald WG, Kletzien RF. Colca JR, et al. Among authors: kletzien rf. Expert Opin Investig Drugs. 2014 Jan;23(1):1-7. doi: 10.1517/13543784.2013.839659. Epub 2013 Sep 27. Expert Opin Investig Drugs. 2014. PMID: 24073940 Review.

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Glucose-6-phosphate dehydrogenase: a "housekeeping" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress.

Kletzien RF, Harris PK, Foellmi LA. Kletzien RF, et al. FASEB J. 1994 Feb;8(2):174-81. doi: 10.1096/fasebj.8.2.8119488. FASEB J. 1994. PMID: 8119488 Review.

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PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.

Tanis SP, Colca JR, Parker TT, Artman GD 3rd, Larsen SD, McDonald WG, Gadwood RC, Kletzien RF, Zeller JB, Lee PH, Adams WJ. Tanis SP, et al. Among authors: kletzien rf. Bioorg Med Chem. 2018 Dec 1;26(22):5870-5884. doi: 10.1016/j.bmc.2018.10.033. Epub 2018 Nov 2. Bioorg Med Chem. 2018. PMID: 30429097 No abstract available.

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The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism.

Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN. Vigueira PA, et al. Among authors: kletzien rf. Exp Physiol. 2017 Aug 1;102(8):985-999. doi: 10.1113/EP086380. Epub 2017 Jul 10. Exp Physiol. 2017. PMID: 28597936 Free PMC article.

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Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.

Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN. Vigueira PA, et al. Among authors: kletzien rf. Cell Rep. 2014 Jun 26;7(6):2042-2053. doi: 10.1016/j.celrep.2014.05.017. Epub 2014 Jun 5. Cell Rep. 2014. PMID: 24910426 Free PMC article.

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Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets.

Rohatgi N, Aly H, Marshall CA, McDonald WG, Kletzien RF, Colca JR, McDaniel ML. Rohatgi N, et al. Among authors: kletzien rf. PLoS One. 2013 May 1;8(5):e62012. doi: 10.1371/journal.pone.0062012. Print 2013. PLoS One. 2013. PMID: 23650507 Free PMC article.

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Inductions by hormones added singly, simultaneously or sequentially: what cultured hepatocytes can tell us about metabolic regulation in the whole animal.

Pariza MW, Kletzien RF, Butcher FR, Potter VR. Pariza MW, et al. Among authors: kletzien rf. Adv Enzyme Regul. 1976;14:103-15. doi: 10.1016/0065-2571(76)90009-1. Adv Enzyme Regul. 1976. PMID: 9786 Review. No abstract available.

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