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Year Number of Results
2010 2
2011 4
2012 3
2013 2
2014 2
2015 2
2016 3
2017 2
2018 4
2019 1
2020 2
2021 0
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22 results
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Page 1
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D. Liang YL, et al. Among authors: koole c. Mol Cell. 2020 Feb 6;77(3):656-668.e5. doi: 10.1016/j.molcel.2020.01.012. Epub 2020 Jan 30. Mol Cell. 2020. PMID: 32004469 Free article.
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM. Liang YL, et al. Among authors: koole c. Nature. 2018 Sep;561(7724):492-497. doi: 10.1038/s41586-018-0535-y. Epub 2018 Sep 12. Nature. 2018. PMID: 30209400 Free PMC article.
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D. Liang YL, et al. Among authors: koole c. Nature. 2018 Mar 1;555(7694):121-125. doi: 10.1038/nature25773. Epub 2018 Feb 21. Nature. 2018. PMID: 29466332
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.
Levine PM, Balana AT, Sturchler E, Koole C, Noda H, Zarzycka B, Daley EJ, Truong TT, Katritch V, Gardella TJ, Wootten D, Sexton PM, McDonald P, Pratt MR. Levine PM, et al. Among authors: koole c. J Am Chem Soc. 2019 Sep 11;141(36):14210-14219. doi: 10.1021/jacs.9b05365. Epub 2019 Aug 28. J Am Chem Soc. 2019. PMID: 31418572 Free PMC article.
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM. Liang YL, et al. Among authors: koole c. ACS Pharmacol Transl Sci. 2020 Mar 20;3(2):263-284. doi: 10.1021/acsptsci.9b00080. eCollection 2020 Apr 10. ACS Pharmacol Transl Sci. 2020. PMID: 32296767 Free PMC article.
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