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Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024).
Woodward DF, Krauss AH, Chen J, Liang Y, Li C, Protzman CE, Bogardus A, Chen R, Kedzie KM, Krauss HA, Gil DW, Kharlamb A, Wheeler LA, Babusis D, Welty D, Tang-Liu DD, Cherukury M, Andrews SW, Burk RM, Garst ME. Woodward DF, et al. Among authors: krauss ha. J Pharmacol Exp Ther. 2003 May;305(2):772-85. doi: 10.1124/jpet.102.047837. Epub 2003 Jan 24. J Pharmacol Exp Ther. 2003. PMID: 12606640
Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds.
Woodward DF, Krauss AH, Chen J, Gil DW, Kedzie KM, Protzman CE, Shi L, Chen R, Krauss HA, Bogardus A, Dinh HT, Wheeler LA, Andrews SW, Burk RM, Gac T, Roof MB, Garst ME, Kaplan LJ, Sachs G, Pierce KL, Regan JW, Ross RA, Chan MF. Woodward DF, et al. Among authors: krauss ha. Br J Pharmacol. 2000 Aug;130(8):1933-43. doi: 10.1038/sj.bjp.0703462. Br J Pharmacol. 2000. PMID: 10952685 Free PMC article.