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2009 2
2011 2
2012 2
2013 1
2021 0
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Page 1
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier.
Wang L, Cherian C, Kugel Desmoulin S, Mitchell-Ryan S, Hou Z, Matherly LH, Gangjee A. Wang L, et al. Among authors: kugel desmoulin s. J Med Chem. 2012 Feb 23;55(4):1758-70. doi: 10.1021/jm201688n. Epub 2012 Feb 3. J Med Chem. 2012. PMID: 22243528 Free PMC article.
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.
Cherian C, Kugel Desmoulin S, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Gangjee A, Matherly LH. Cherian C, et al. Among authors: kugel desmoulin s. Cancer Chemother Pharmacol. 2013 Apr;71(4):999-1011. doi: 10.1007/s00280-013-2094-0. Epub 2013 Feb 15. Cancer Chemother Pharmacol. 2013. PMID: 23412628 Free PMC article.
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.
Deng Y, Zhou X, Kugel Desmoulin S, Wu J, Cherian C, Hou Z, Matherly LH, Gangjee A. Deng Y, et al. Among authors: kugel desmoulin s. J Med Chem. 2009 May 14;52(9):2940-51. doi: 10.1021/jm8011323. J Med Chem. 2009. PMID: 19371039 Free PMC article.
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter.
Kugel Desmoulin S, Wang L, Hales E, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH. Kugel Desmoulin S, et al. Mol Pharmacol. 2011 Dec;80(6):1096-107. doi: 10.1124/mol.111.073833. Epub 2011 Sep 22. Mol Pharmacol. 2011. PMID: 21940787 Free PMC article.
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Larson Gedman A, Chen Q, Kugel Desmoulin S, Ge Y, LaFiura K, Haska CL, Cherian C, Devidas M, Linda SB, Taub JW, Matherly LH. Larson Gedman A, et al. Among authors: kugel desmoulin s. Leukemia. 2009 Aug;23(8):1417-25. doi: 10.1038/leu.2009.64. Epub 2009 Apr 2. Leukemia. 2009. PMID: 19340001 Free PMC article.