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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1988 2
1991 1
1992 1
1994 1
1995 1
1996 1
1997 1
1998 1
1999 4
2000 2
2003 1
2004 1
2006 1
2007 1
2008 2
2009 2
2010 1
2011 4
2012 2
2013 3
2014 5
2015 1
2016 4
2017 3
2018 6
2019 4
2020 3
2021 3
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62 results
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Page 1
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F. Posternak G, et al. Among authors: kurinov i. Nat Chem Biol. 2020 Nov;16(11):1170-1178. doi: 10.1038/s41589-020-0609-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778845 Free PMC article.
MEK drives BRAF activation through allosteric control of KSR proteins.
Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M. Lavoie H, et al. Among authors: kurinov i. Nature. 2018 Feb 22;554(7693):549-553. doi: 10.1038/nature25478. Epub 2018 Feb 12. Nature. 2018. PMID: 29433126 Free PMC article.
Structural mechanism of ligand activation in human calcium-sensing receptor.
Geng Y, Mosyak L, Kurinov I, Zuo H, Sturchler E, Cheng TC, Subramanyam P, Brown AP, Brennan SC, Mun HC, Bush M, Chen Y, Nguyen TX, Cao B, Chang DD, Quick M, Conigrave AD, Colecraft HM, McDonald P, Fan QR. Geng Y, et al. Among authors: kurinov i. Elife. 2016 Jul 19;5:e13662. doi: 10.7554/eLife.13662. Elife. 2016. PMID: 27434672 Free PMC article.
Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.
Assadieskandar A, Yu C, Maisonneuve P, Kurinov I, Sicheri F, Zhang C. Assadieskandar A, et al. Among authors: kurinov i. ACS Med Chem Lett. 2019 Jun 4;10(7):1074-1080. doi: 10.1021/acsmedchemlett.9b00194. eCollection 2019 Jul 11. ACS Med Chem Lett. 2019. PMID: 31312411 Free PMC article.
Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor.
Zuo H, Glaaser I, Zhao Y, Kurinov I, Mosyak L, Wang H, Liu J, Park J, Frangaj A, Sturchler E, Zhou M, McDonald P, Geng Y, Slesinger PA, Fan QR. Zuo H, et al. Among authors: kurinov i. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8370-8379. doi: 10.1073/pnas.1903024116. Epub 2019 Apr 10. Proc Natl Acad Sci U S A. 2019. PMID: 30971491 Free PMC article.
Effects of rigidity on the selectivity of protein kinase inhibitors.
Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C. Assadieskandar A, et al. Among authors: kurinov i. Eur J Med Chem. 2018 Feb 25;146:519-528. doi: 10.1016/j.ejmech.2018.01.053. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29407977 Free PMC article.
MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC. Couzens AL, et al. Among authors: kurinov i. Mol Cell Proteomics. 2017 Jun;16(6):1098-1110. doi: 10.1074/mcp.M116.065490. Epub 2017 Apr 3. Mol Cell Proteomics. 2017. PMID: 28373298 Free PMC article.
62 results
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