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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics.
Zhao N, Ho JSY, Meng F, Zheng S, Kurland AP, Tian L, Rea-Moreno M, Song X, Seo JS, Kaniskan HÜ, Te Velthuis AJW, Tortorella D, Chen YW, Johnson JR, Jin J, Marazzi I. Zhao N, et al. Among authors: kurland ap. Cell Host Microbe. 2023 Jul 12;31(7):1154-1169.e10. doi: 10.1016/j.chom.2023.05.030. Epub 2023 Jun 5. Cell Host Microbe. 2023. PMID: 37339625 Free article.
Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling.
Johnson JR, Crosby DC, Hultquist JF, Kurland AP, Adhikary P, Li D, Marlett J, Swann J, Hüttenhain R, Verschueren E, Johnson TL, Newton BW, Shales M, Simon VA, Beltrao P, Frankel AD, Marson A, Cox JS, Fregoso OI, Young JAT, Krogan NJ. Johnson JR, et al. Among authors: kurland ap. Cell Rep. 2022 Apr 12;39(2):110690. doi: 10.1016/j.celrep.2022.110690. Cell Rep. 2022. PMID: 35417684 Free PMC article.
SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication.
Higgins CA, Nilsson-Payant BE, Bonaventure B, Kurland AP, Ye C, Yaron TM, Johnson JL, Adhikary P, Golynker I, Panis M, Danziger O, Rosenberg BR, Cantley LC, Martínez-Sobrido L, tenOever B, Johnson JR. Higgins CA, et al. Among authors: kurland ap. mBio. 2023 Aug 31;14(4):e0100723. doi: 10.1128/mbio.01007-23. Epub 2023 Jun 22. mBio. 2023. PMID: 37345956 Free PMC article.
Endosomal cAMP production broadly impacts the cellular phosphoproteome.
Tsvetanova NG, Trester-Zedlitz M, Newton BW, Peng GE, Johnson JR, Jimenez-Morales D, Kurland AP, Krogan NJ, von Zastrow M. Tsvetanova NG, et al. Among authors: kurland ap. J Biol Chem. 2021 Jul;297(1):100907. doi: 10.1016/j.jbc.2021.100907. Epub 2021 Jun 22. J Biol Chem. 2021. PMID: 34166681 Free PMC article.
Immunization of Mice with Virus-Like Vesicles of Kaposi Sarcoma-Associated Herpesvirus Reveals a Role for Antibodies Targeting ORF4 in Activating Complement-Mediated Neutralization.
Lam AK, Roshan R, Miley W, Labo N, Zhen J, Kurland AP, Cheng C, Huang H, Teng PL, Harelson C, Gong D, Tam YK, Radu CG, Epeldegui M, Johnson JR, Zhou ZH, Whitby D, Wu TT. Lam AK, et al. Among authors: kurland ap. J Virol. 2023 Feb 28;97(2):e0160022. doi: 10.1128/jvi.01600-22. Epub 2023 Feb 9. J Virol. 2023. PMID: 36757205 Free PMC article.