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Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Zhang X, et al. Among authors: kwilasz aj. FASEB J. 2019 Aug;33(8):9577-9587. doi: 10.1096/fj.201900173RRR. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31162938 Free PMC article.
The therapeutic potential of interleukin-10 in neuroimmune diseases.
Kwilasz AJ, Grace PM, Serbedzija P, Maier SF, Watkins LR. Kwilasz AJ, et al. Neuropharmacology. 2015 Sep;96(Pt A):55-69. doi: 10.1016/j.neuropharm.2014.10.020. Epub 2014 Nov 4. Neuropharmacology. 2015. PMID: 25446571 Free PMC article. Review.
Effects of opioid receptor ligands in rats trained to discriminate 22 from 2 hours of food deprivation suggest a lack of opioid involvement in eating for hunger.
Jewett DC, Klockars A, Smith TR, Brunton C, Head MA, Tham RL, Kwilasz AJ, Hahn TW, Wiebelhaus JM, Ewan EE, Carroll RM, Grace MK, Levine AS, Olszewski PK. Jewett DC, et al. Among authors: kwilasz aj. Behav Brain Res. 2020 Feb 17;380:112369. doi: 10.1016/j.bbr.2019.112369. Epub 2019 Nov 17. Behav Brain Res. 2020. PMID: 31743731
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.
Kwilasz AJ, Todd LS, Duran-Malle JC, Schrama AEW, Mitten EH, Larson TA, Clements MA, Harris KM, Litwiler ST, Wang X, Van Dam AM, Maier SF, Rice KC, Watkins LR, Barrientos RM. Kwilasz AJ, et al. Behav Brain Res. 2021 Jan 1;396:112896. doi: 10.1016/j.bbr.2020.112896. Epub 2020 Sep 6. Behav Brain Res. 2021. PMID: 32905811
Prior voluntary wheel running attenuates neuropathic pain.
Grace PM, Fabisiak TJ, Green-Fulgham SM, Anderson ND, Strand KA, Kwilasz AJ, Galer EL, Walker FR, Greenwood BN, Maier SF, Fleshner M, Watkins LR. Grace PM, et al. Among authors: kwilasz aj. Pain. 2016 Sep;157(9):2012-23. doi: 10.1097/j.pain.0000000000000607. Pain. 2016. PMID: 27355182 Free PMC article.
Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
Kwilasz AJ, Green Fulgham SM, Duran-Malle JC, Schrama AEW, Mitten EH, Todd LS, Patel HP, Larson TA, Clements MA, Harris KM, Litwiler ST, Harvey LO Jr, Maier SF, Chavez RA, Rice KC, Van Dam AM, Watkins LR. Kwilasz AJ, et al. Brain Behav Immun. 2021 Mar;93:80-95. doi: 10.1016/j.bbi.2020.12.016. Epub 2021 Jan 7. Brain Behav Immun. 2021. PMID: 33358978
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