Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase.
Hlozkova K, Vasylkivska M, Boufersaoui A, Marzullo B, Kolarik M, Alquezar-Artieda N, Shaikh M, Alaei NF, Zaliova M, Zwyrtkova M, Bakardijeva-Mihaylova V, Alberich-Jorda M, Trka J, Tennant DA, Starkova J.
Hlozkova K, et al.
Cancer Lett. 2024 Nov 28;605:217242. doi: 10.1016/j.canlet.2024.217242. Epub 2024 Sep 11.
Cancer Lett. 2024.
PMID: 39270769
Free article.
We have described such a scenario in leukemic cells treated with L-asparaginase (ASNase). Clinical effect of ASNase is based on nutrient stress achieved by its dual enzymatic action which leads to depletion of asparagine and glutamine and is accompanied with elevated aspar …
We have described such a scenario in leukemic cells treated with L-asparaginase (ASNase). Clinical effect of ASNase is based on nutri …