Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial.
Devereux G, Cotton S, Fielding S, McMeekin N, Barnes PJ, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, De Soyza A, Gompertz S, Haughney J, Innes K, Kaniewska J, Lee A, Morice A, Norrie J, Sullivan A, Wilson A, Price D.
Devereux G, et al. Among authors: sullivan a.
JAMA. 2018 Oct 16;320(15):1548-1559. doi: 10.1001/jama.2018.14432.
JAMA. 2018.
PMID: 30326124
Free PMC article.
Clinical Trial.
Preclinical investigations have demonstrated that low plasma concentrations (1-5 mg/L) of theophylline enhance antiinflammatory effects of corticosteroids in COPD. ...INTERVENTIONS: Participants were randomized to receive low-dose theophylline (200 mg once or twice per day …
Preclinical investigations have demonstrated that low plasma concentrations (1-5 mg/L) of theophylline enhance antiinflammatory effec …