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Year Number of Results
2011 2
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31 results

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L1TD1 - a prognostic marker for colon cancer.
Chakroborty D, Emani MR, Klén R, Böckelman C, Hagström J, Haglund C, Ristimäki A, Lahesmaa R, Elo LL. Chakroborty D, et al. BMC Cancer. 2019 Jul 23;19(1):727. doi: 10.1186/s12885-019-5952-2. BMC Cancer. 2019. PMID: 31337362 Free PMC article.
RESULTS: We found L1TD1 as a novel positive prognostic marker for colon cancer. Increased expression of L1TD1 associated with longer disease-free survival in all the three data sets. Our results were in contrast to a previous study on medulloblastoma, where high exp …
RESULTS: We found L1TD1 as a novel positive prognostic marker for colon cancer. Increased expression of L1TD1 associated with …
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition.
Kavaklioglu G, Podhornik A, Vcelkova T, Marjanovic J, Beck MA, Phan-Canh T, Mair T, Miccolo C, Drino A, Doni M, Egger G, Chiocca S, Modic M, Seiser C. Kavaklioglu G, et al. Elife. 2025 Mar 20;13:RP96850. doi: 10.7554/eLife.96850. Elife. 2025. PMID: 40112032 Free PMC article.
Our findings reveal that DNA hypomethylation induces the expression of L1TD1 in HAP1 human tumor cells. L1TD1 depletion significantly modulates both the proteome and transcriptome and thereby reduces cell viability. ...Our data suggest that L1TD1 collaborates …
Our findings reveal that DNA hypomethylation induces the expression of L1TD1 in HAP1 human tumor cells. L1TD1 depletion signif …
The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency.
Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. Emani MR, et al. Stem Cell Reports. 2015 Mar 10;4(3):519-28. doi: 10.1016/j.stemcr.2015.01.014. Epub 2015 Feb 19. Stem Cell Reports. 2015. PMID: 25702638 Free PMC article.
Our data reveal that L1TD1 has an important role in RNA splicing, translation, protein traffic, and degradation. L1TD1 interacts with multiple stem-cell-specific proteins, many of which are still uncharacterized in the context of development. ...
Our data reveal that L1TD1 has an important role in RNA splicing, translation, protein traffic, and degradation. L1TD1 interac …
L1TD1 is a marker for undifferentiated human embryonic stem cells.
Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ. Wong RC, et al. PLoS One. 2011 Apr 29;6(4):e19355. doi: 10.1371/journal.pone.0019355. PLoS One. 2011. PMID: 21559406 Free PMC article.
Our results show that L1TD1 is enriched in the SSEA4-positive or TRA160-positive population of hESC. Using chromatin immunoprecipitation we found enriched association of Nanog to the predicted promoter region of L1TD1. Furthermore, siRNA-mediated knockdown of Nanog …
Our results show that L1TD1 is enriched in the SSEA4-positive or TRA160-positive population of hESC. Using chromatin immunoprecipitat …
SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers.
Altenberger C, Heller G, Ziegler B, Tomasich E, Marhold M, Topakian T, Müllauer L, Heffeter P, Lang G, End-Pfützenreuter A, Döme B, Arns BM, Klepetko W, Zielinski CC, Zöchbauer-Müller S. Altenberger C, et al. Mol Cancer. 2017 Jan 5;16(1):1. doi: 10.1186/s12943-016-0568-5. Mol Cancer. 2017. PMID: 28093071 Free PMC article.
Immunohistochemistry revealed a close association between SPAG6/L1TD1 methylation and downregulated protein expression of these genes. Moreover, by performing functional assays we observed reduced cell growth, proliferation and viability of pCMV6-L1TD1 transfected N …
Immunohistochemistry revealed a close association between SPAG6/L1TD1 methylation and downregulated protein expression of these genes …
ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency.
Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S. Iwabuchi KA, et al. PLoS One. 2011;6(5):e20461. doi: 10.1371/journal.pone.0020461. Epub 2011 May 26. PLoS One. 2011. PMID: 21637830 Free PMC article.
However, the global network of factors and their full signaling cascade is still unclear. In this study, we found that ECAT11 (L1td1) is one of the ESC-associated transcripts harboring a truncated fragment of ORF-1, a component of the L1 retrotransposable element. ...Our d …
However, the global network of factors and their full signaling cascade is still unclear. In this study, we found that ECAT11 (L1td1) …
Dissolution of ribonucleoprotein condensates by the embryonic stem cell protein L1TD1.
Jin SW, Seong Y, Yoon D, Kwon YS, Song H. Jin SW, et al. Nucleic Acids Res. 2024 Apr 12;52(6):3310-3326. doi: 10.1093/nar/gkad1244. Nucleic Acids Res. 2024. PMID: 38165001 Free PMC article.
Here, we determined RNAs associated with L1TD1 and found that, like ORF1p, L1TD1 binds L1 RNAs and localizes to high-density ribonucleoprotein (RNP) condensates. Unexpectedly, L1TD1 enhanced the translation of a subset of mRNAs enriched in the condensates. …
Here, we determined RNAs associated with L1TD1 and found that, like ORF1p, L1TD1 binds L1 RNAs and localizes to high-density r …
Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in Medulloblastoma.
Santos MC, Silva PB, Rodini CO, Furukawa G, Marco Antonio DS, Zanotto-Filho A, Moreira JC, Okamoto OK. Santos MC, et al. Stem Cells Dev. 2015 Nov 15;24(22):2700-8. doi: 10.1089/scd.2015.0052. Epub 2015 Aug 10. Stem Cells Dev. 2015. PMID: 26159230
L1TD1 is still poorly characterized and its expression pattern and function in cancer cells are virtually unknown. ...Conversely to what is reported during normal cell differentiation, when differentiated cells remain healthy, despite L1TD1 downregulation, depletion …
L1TD1 is still poorly characterized and its expression pattern and function in cancer cells are virtually unknown. ...Conversely to w …
RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation.
Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R. Närvä E, et al. Stem Cells. 2012 Mar;30(3):452-60. doi: 10.1002/stem.1013. Stem Cells. 2012. PMID: 22162396 Free PMC article.
Depletion of L1TD1 results in immediate downregulation of OCT4 and NANOG. Furthermore, we demonstrate that OCT4, SOX2, and NANOG all bind to the promoter of L1TD1. Moreover, L1TD1 is highly expressed in seminomas, and depletion of L1TD1 in these cancer …
Depletion of L1TD1 results in immediate downregulation of OCT4 and NANOG. Furthermore, we demonstrate that OCT4, SOX2, and NANOG all …
Integrated interactome, proteomic and functional analyses reveal molecular pathways driving L1TD1-induced aggressiveness in CNS embryonal tumor cells.
Mitsugi TG, Sherwood M, Jandrey EHF, Assoni AF, Bell J, Coke B, Skipp P, Ewing R, Okamoto OK. Mitsugi TG, et al. FEBS Lett. 2025 Apr;599(7):1029-1045. doi: 10.1002/1873-3468.70002. Epub 2025 Feb 6. FEBS Lett. 2025. PMID: 39912397
Here, we used affinity purification coupled to mass spectrometry to map the L1TD1 interactome, and global proteomics to assess proteins differentially regulated by L1TD1 expression in patient-derived embryonal CNS tumor cell lines. We identified novel L1TD1 i …
Here, we used affinity purification coupled to mass spectrometry to map the L1TD1 interactome, and global proteomics to assess protei …
31 results