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Page 1
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism.
Peralta RM, Xie B, Lontos K, Nieves-Rosado H, Spahr K, Joshi S, Ford BR, Quann K, Frisch AT, Dean V, Philbin M, Cillo AR, Gingras S, Poholek AC, Kane LP, Rivadeneira DB, Delgoffe GM. Peralta RM, et al. Among authors: lontos k. Nat Immunol. 2024 Dec;25(12):2297-2307. doi: 10.1038/s41590-024-01999-3. Epub 2024 Nov 8. Nat Immunol. 2024. PMID: 39516648 Free PMC article.
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy.
Frisch AT, Wang Y, Xie B, Yang A, Ford BR, Joshi S, Kedziora KM, Peralta R, Wilfahrt D, Mullett SJ, Spahr K, Lontos K, Jana JA, Dean VG, Gunn WG, Gelhaus S, Poholek AC, Rivadeneira DB, Delgoffe GM. Frisch AT, et al. Among authors: lontos k. Cell Metab. 2025 Apr 1;37(4):870-885.e8. doi: 10.1016/j.cmet.2024.12.007. Epub 2025 Jan 28. Cell Metab. 2025. PMID: 39879981 Free PMC article.
Tumour interstitial fluid-enriched phosphoethanolamine suppresses T cell function.
Wang Y, Wilfahrt D, Jonker P, Lontos K, Cai C, Cameron B, Xie B, Peralta RM, Schoedel ER, Gunn WG, AminiTabrizi R, Shah H, Rivadeneira DB, Muir A, Delgoffe GM. Wang Y, et al. Among authors: lontos k. Nat Cell Biol. 2025 May;27(5):835-846. doi: 10.1038/s41556-025-01650-9. Epub 2025 Apr 21. Nat Cell Biol. 2025. PMID: 40258951
Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer.
Rivadeneira DB, Thosar S, Quann K, Gunn WG, Dean VG, Xie B, Parise A, McGovern AC, Spahr K, Lontos K, Barnes RP, Bruchez MP, Opresko PL, Delgoffe GM. Rivadeneira DB, et al. Among authors: lontos k. Immunity. 2025 Oct 14;58(10):2524-2540.e5. doi: 10.1016/j.immuni.2025.08.008. Epub 2025 Sep 9. Immunity. 2025. PMID: 40930086 Free article.
The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis.
Lontos K, Adamik J, Tsagianni A, Galson DL, Chirgwin JM, Suvannasankha A. Lontos K, et al. Front Endocrinol (Lausanne). 2018 Jun 19;9:322. doi: 10.3389/fendo.2018.00322. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 29971044 Free PMC article. Review.
32 results