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Page 1
Inhibition of IRF5 hyperactivation protects from lupus onset and severity.
Song S, De S, Nelson V, Chopra S, LaPan M, Kampta K, Sun S, He M, Thompson CD, Li D, Shih T, Tan N, Al-Abed Y, Capitle E, Aranow C, Mackay M, Clapp WL, Barnes BJ. Song S, et al. Among authors: lapan m. J Clin Invest. 2020 Dec 1;130(12):6700-6717. doi: 10.1172/JCI120288. J Clin Invest. 2020. PMID: 32897883 Free PMC article. Clinical Trial.
Loss of IRF5 increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis.
Brune Z, Li D, Song S, Li DI, Castro I, Rasquinha R, Rice MR, Guo Q, Kampta K, Moss M, Lallo M, Pimenta E, Somerville C, Lapan M, Nelson V, Dos Santos CO, Blanc L, Pruitt K, Barnes BJ. Brune Z, et al. Among authors: lapan m. bioRxiv [Preprint]. 2023 May 1:2023.05.01.538998. doi: 10.1101/2023.05.01.538998. bioRxiv. 2023. PMID: 37292919 Free PMC article. Preprint.
Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a-based and Siglece-based vaccination induces antitumor immunity and inhibits metastasis.
Carter JA, Matta B, Battaglia J, Somerville C, Harris BD, LaPan M, Atwal GS, Barnes BJ. Carter JA, et al. Among authors: lapan m. J Immunother Cancer. 2023 Dec 22;11(12):e007935. doi: 10.1136/jitc-2023-007935. J Immunother Cancer. 2023. PMID: 38135347 Free PMC article.
Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization.
Banga J, Srinivasan D, Sun CC, Thompson CD, Milletti F, Huang KS, Hamilton S, Song S, Hoffman AF, Qin YG, Matta B, LaPan M, Guo Q, Lu G, Li D, Qian H, Bolin DR, Liang L, Wartchow C, Qiu J, Downing M, Narula S, Fotouhi N, DeMartino JA, Tan SL, Chen G, Barnes BJ. Banga J, et al. Among authors: lapan m. Sci Adv. 2020 May 15;6(20):eaay1057. doi: 10.1126/sciadv.aay1057. eCollection 2020 May. Sci Adv. 2020. PMID: 32440537 Free PMC article.
Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasis.
Carter JA, Matta B, Battaglia J, Somerville C, Harris BD, LaPan M, Atwal GS, Barnes BJ. Carter JA, et al. Among authors: lapan m. bioRxiv [Preprint]. 2023 May 10:2023.05.09.539617. doi: 10.1101/2023.05.09.539617. bioRxiv. 2023. Update in: J Immunother Cancer. 2023 Dec 22;11(12):e007935. doi: 10.1136/jitc-2023-007935. PMID: 37214884 Free PMC article. Updated. Preprint.