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Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M. Calvisi DF, et al. Among authors: ladu s. Gastroenterology. 2011 Mar;140(3):1071-83. doi: 10.1053/j.gastro.2010.12.006. Epub 2010 Dec 11. Gastroenterology. 2011. PMID: 21147110 Free PMC article.

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EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.

Pellegrino R, Calvisi DF, Neumann O, Kolluru V, Wesely J, Chen X, Wang C, Wuestefeld T, Ladu S, Elgohary N, Bermejo JL, Radlwimmer B, Zörnig M, Zender L, Dombrowski F, Evert M, Schirmacher P, Longerich T. Pellegrino R, et al. Among authors: ladu s. Hepatology. 2014 May;59(5):1886-99. doi: 10.1002/hep.26954. Epub 2014 Mar 27. Hepatology. 2014. PMID: 24285179 Free PMC article.

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Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma.

Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K. Tschaharganeh DF, et al. Among authors: ladu s. Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. Gastroenterology. 2013. PMID: 23419361 Free PMC article.

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Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.

Wang C, Delogu S, Ho C, Lee SA, Gui B, Jiang L, Ladu S, Cigliano A, Dombrowski F, Evert M, Calvisi DF, Chen X. Wang C, et al. Among authors: ladu s. J Hepatol. 2012 Sep;57(3):577-83. doi: 10.1016/j.jhep.2012.04.026. Epub 2012 May 19. J Hepatol. 2012. PMID: 22617155 Free PMC article.

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The SHP-1 expression is associated with cytokines and psychopathological status in unmedicated first episode schizophrenia patients.

Pesce M, Ferrone A, Rizzuto A, Tatangelo R, Iezzi I, Ladu S, Franceschelli S, Speranza L, Patruno A, Felaco M, Grilli A. Pesce M, et al. Among authors: ladu s. Brain Behav Immun. 2014 Oct;41:251-60. doi: 10.1016/j.bbi.2014.04.008. Epub 2014 Apr 30. Brain Behav Immun. 2014. PMID: 24793756

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Synergistic role of Sprouty2 inactivation and c-Met up-regulation in mouse and human hepatocarcinogenesis.

Lee SA, Ladu S, Evert M, Dombrowski F, De Murtas V, Chen X, Calvisi DF. Lee SA, et al. Among authors: ladu s. Hepatology. 2010 Aug;52(2):506-17. doi: 10.1002/hep.23681. Hepatology. 2010. PMID: 20683950 Free PMC article.

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Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma.

Pellegrino R, Calvisi DF, Ladu S, Ehemann V, Staniscia T, Evert M, Dombrowski F, Schirmacher P, Longerich T. Pellegrino R, et al. Among authors: ladu s. Hepatology. 2010 Mar;51(3):857-68. doi: 10.1002/hep.23467. Hepatology. 2010. PMID: 20112253

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Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer.

Calvisi DF, Ladu S, Conner EA, Seo D, Hsieh JT, Factor VM, Thorgeirsson SS. Calvisi DF, et al. Among authors: ladu s. J Hepatol. 2011 Feb;54(2):311-9. doi: 10.1016/j.jhep.2010.06.036. Epub 2010 Sep 7. J Hepatol. 2011. PMID: 21067840 Free PMC article.

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Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.

Calvisi DF, Ladu S, Gorden A, Farina M, Conner EA, Lee JS, Factor VM, Thorgeirsson SS. Calvisi DF, et al. Among authors: ladu s. Gastroenterology. 2006 Apr;130(4):1117-28. doi: 10.1053/j.gastro.2006.01.006. Gastroenterology. 2006. PMID: 16618406

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Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma.

Calvisi DF, Ladu S, Gorden A, Farina M, Lee JS, Conner EA, Schroeder I, Factor VM, Thorgeirsson SS. Calvisi DF, et al. Among authors: ladu s. J Clin Invest. 2007 Sep;117(9):2713-22. doi: 10.1172/JCI31457. J Clin Invest. 2007. PMID: 17717605 Free PMC article.

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