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A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.
Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, Valikhani D, Weerasinghe NW, Létourneau M, Thibodeaux CJ, Doucet N, Baron C, Copp JN, Pelletier JN. Lemay-St-Denis C, et al. Among authors: lafontaine k. Philos Trans R Soc Lond B Biol Sci. 2023 Feb 27;378(1871):20220040. doi: 10.1098/rstb.2022.0040. Epub 2023 Jan 11. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 36633286 Free PMC article.
Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance.
Cellier-Goetghebeur S, Lafontaine K, Lemay-St-Denis C, Tsamo P, Bonneau-Burke A, Copp JN, Pelletier JN. Cellier-Goetghebeur S, et al. Among authors: lafontaine k. Antibiotics (Basel). 2022 Dec 7;11(12):1768. doi: 10.3390/antibiotics11121768. Antibiotics (Basel). 2022. PMID: 36551425 Free PMC article.