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260 results

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LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
Fang Y, Dou R, Huang S, Han L, Fu H, Yang C, Song J, Zheng J, Zhang X, Liu K, Xiang Z, Zhang X, Wang S, Xiong B. Fang Y, et al. Int J Biol Sci. 2022 Apr 24;18(7):3082-3101. doi: 10.7150/ijbs.70524. eCollection 2022. Int J Biol Sci. 2022. PMID: 35541892 Free PMC article.
Gastric cancer peritoneal metastasis is a complex biological process which is corresponded with disharmony within dysfunctional adipose tissue and metabolism reprogramming. Laminin gamma 1 (LAMC1) is highly expressed in cancer cells of peritoneal metastatic sites, however, …
Gastric cancer peritoneal metastasis is a complex biological process which is corresponded with disharmony within dysfunctional adipose tiss …
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage.
Wu Q, Yuan K, Yao Y, Yao J, Shao J, Meng Y, Wu P, Shi H. Wu Q, et al. Exp Neurol. 2024 Jun;376:114776. doi: 10.1016/j.expneurol.2024.114776. Epub 2024 Apr 10. Exp Neurol. 2024. PMID: 38609046
Recent evidence suggests that Laminin subunit gamma 1 (LAMC1) is essential for cell survival and proliferation. However, the effects of LAMC1 on early brain injury after SAH and the underlying mechanisms are unknown. ...Recombinant LAMC1 (rLAMC1) was administ …
Recent evidence suggests that Laminin subunit gamma 1 (LAMC1) is essential for cell survival and proliferation. However, the effects …
LAMC1 is a Novel Prognostic Factor and a Potential Therapeutic Target in Gastric Cancer.
Xi D, Jia Q, Liu X, Zhang L, Xu B, Ma Z, Ma Y, Yu Y, Zhang F, Chen H. Xi D, et al. Int J Gen Med. 2022 Mar 19;15:3183-3198. doi: 10.2147/IJGM.S353289. eCollection 2022. Int J Gen Med. 2022. PMID: 35342300 Free PMC article.
The GEPIA2 and TIMER databases were used to validate the differential expression of LAMC1. The relationship between LAMC1 and the prognosis of GC was analysed by the KM. ...Real-time fluorescence quantitative PCR (RT-qPCR) was used to reidentify the expression of …
The GEPIA2 and TIMER databases were used to validate the differential expression of LAMC1. The relationship between LAMC1 and …
High LAMC1 expression in glioma is associated with poor prognosis.
Liu J, Liu D, Yang Z, Yang Z. Liu J, et al. Onco Targets Ther. 2019 May 29;12:4253-4260. doi: 10.2147/OTT.S205333. eCollection 2019. Onco Targets Ther. 2019. PMID: 31213842 Free PMC article.
The aim of this study was to evaluate the expression of LAMC1 and its clinical significance. Patients and methods: LAMC1 protein expression in 52 fresh-frozen specimens of different pathological grade gliomas and 5 normal brain tissues was detected by Western blotti …
The aim of this study was to evaluate the expression of LAMC1 and its clinical significance. Patients and methods: LAMC1 prote …
HIF-1alpha-mediated LAMC1 overexpression is an unfavorable predictor of prognosis for glioma patients: evidence from pan-cancer analysis and validation experiments.
Bai J, Zhao Y, Shi K, Fan Y, Ha Y, Chen Y, Luo B, Lu Y, Jie W, Shen Z. Bai J, et al. J Transl Med. 2024 Apr 27;22(1):391. doi: 10.1186/s12967-024-05218-3. J Transl Med. 2024. PMID: 38678297 Free PMC article.
Knowledge of the biological features and clinical relevance of LAMC1 in cancers remains limited. METHODS: We conducted comprehensive bioinformatics analysis of LAMC1 gene expression and clinical relevance in pan-cancer datasets of public databases and validated L …
Knowledge of the biological features and clinical relevance of LAMC1 in cancers remains limited. METHODS: We conducted comprehensive …
Lamc1 promotes osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells.
Zhao L, Liu S, Peng Y, Zhang J. Zhao L, et al. Sci Rep. 2024 Aug 23;14(1):19592. doi: 10.1038/s41598-024-69629-4. Sci Rep. 2024. PMID: 39179716 Free PMC article.
Subsequently, the target genes were validated using publicly available single-cell RNA-seq data from mouse BMSCs. Lamc1 exhibited predominant distribution in adipocytes and osteoblasts, primarily during the G2/M phase. ...Knockdown of Lamc1 inhibited adipogenic and …
Subsequently, the target genes were validated using publicly available single-cell RNA-seq data from mouse BMSCs. Lamc1 exhibited pre …
LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer.
Kunitomi H, Kobayashi Y, Wu RC, Takeda T, Tominaga E, Banno K, Aoki D. Kunitomi H, et al. J Gynecol Oncol. 2020 Mar;31(2):e11. doi: 10.3802/jgo.2020.31.e11. Epub 2019 Aug 21. J Gynecol Oncol. 2020. PMID: 31912669 Free PMC article.
Within the endometrial cancer cases, we analyzed the association of LAMC1 overexpression with clinicopathological factors and prognosis. Furthermore, to indentify genes influenced by LAMC1 overexpression, we transfected HEC50B and SPAC-S cells with siRNA targeting …
Within the endometrial cancer cases, we analyzed the association of LAMC1 overexpression with clinicopathological factors and prognos …
LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis.
Wang YQ, Huang G, Chen J, Cao H, Xu WT. Wang YQ, et al. Breast Cancer Res Treat. 2021 Jul;188(1):1-14. doi: 10.1007/s10549-021-06190-y. Epub 2021 Mar 29. Breast Cancer Res Treat. 2021. PMID: 33782812
QRT-PCR and Western blotting were employed to measure expression levels of SNHG6, miR-543, LAMC1, EMT-related proteins, and PI3K/AKT pathway. Dual-luciferase assay was performed to validate interactions of SNHG6/miR-543 and miR-543/LAMC1. ...CONCLUSION: SNHG6 promot …
QRT-PCR and Western blotting were employed to measure expression levels of SNHG6, miR-543, LAMC1, EMT-related proteins, and PI3K/AKT …
LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies.
Han ZR, Jiang XL, Fan WC. Han ZR, et al. Neoplasma. 2021 Jul;68(4):711-718. doi: 10.4149/neo_2021_201117N1239. Epub 2021 Apr 23. Neoplasma. 2021. PMID: 33884884
Gastric cancer is a common malignancy in the alimentary system. The laminin subunit gamma 1 (LAMC1) is an important oncogene in human cancers. However, how and whether LAMC1 takes part in gastric cancer progression is largely uncertain. ...Our results showed LAMC …
Gastric cancer is a common malignancy in the alimentary system. The laminin subunit gamma 1 (LAMC1) is an important oncogene in human …
Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway.
Ye G, Qin Y, Wang S, Pan D, Xu S, Wu C, Wang X, Wang J, Ye H, Shen H. Ye G, et al. Cancer Biol Ther. 2019;20(5):711-719. doi: 10.1080/15384047.2018.1564558. Epub 2019 Feb 12. Cancer Biol Ther. 2019. PMID: 30755064 Free PMC article.
The effects of PKM2 were similar to that of Lamc1 and markedly counteracted the effects of Lamc1 down-regulation. In addition, Lamc1-induced increase in PKM2 expression was strongly attenuated by a PI3K inhibitor, LY294002 or a si-p110 PI3K, with a significan …
The effects of PKM2 were similar to that of Lamc1 and markedly counteracted the effects of Lamc1 down-regulation. In addition, …
260 results