Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D, Liu X, Yan C.
Chen ZP, et al.
Nat Neurosci. 2023 Apr;26(4):542-554. doi: 10.1038/s41593-023-01288-6. Epub 2023 Mar 20.
Nat Neurosci. 2023.
PMID: 36941428
Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the formation of lipid-accumulated reactive astrocytes (LARAs), a new reactive astrocyte subtype characterized by elevated APO …
Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes le …