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121 results

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LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.
Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B. Yu H, et al. Circulation. 2021 May 18;143(20):2007-2022. doi: 10.1161/CIRCULATIONAHA.120.050812. Epub 2021 Mar 5. Circulation. 2021. PMID: 33663221
METHODS: We assessed LARP7 expression in human HF and in nonhuman primate and mouse HF models. To study the function of LARP7 in heart, we generated global and cardiac-specific LARP7 knockout mice. We acutely abolished LARP7 in mature cardiomyocytes by …
METHODS: We assessed LARP7 expression in human HF and in nonhuman primate and mouse HF models. To study the function of LARP7 …
LARP7 protects against ischemic brain injury by modulating NLRP3 deacetylation to suppress neuronal pyroptosis.
Tang H, Wen J, Yang Q, Wang L, Qin T, Ren Y, Zhao Y, Wu Y, Li C, Li J, He Y, Huang J, Zi W, Yang Q. Tang H, et al. J Neuroinflammation. 2025 Dec 5;23(1):13. doi: 10.1186/s12974-025-03649-3. J Neuroinflammation. 2025. PMID: 41351020 Free PMC article.
To elucidate the role of LARP7 in ischemic stroke, we generated neuron-specific LARP7 knockout mice, and employed a lentiviral delivery system for neuronal LARP7 overexpression. ...Targeting LARP7 could represent a promising therapeutic strategy for is …
To elucidate the role of LARP7 in ischemic stroke, we generated neuron-specific LARP7 knockout mice, and employed a lentiviral …
LARP7 Contributes to Glucose-Induced Cardiac Dysfunction, Apoptosis and Fibrosis by Inhibiting the Degradation of STING.
Sun J, Wang Z, Duan Y, Liu C, Zhao S, Deng J. Sun J, et al. Front Biosci (Landmark Ed). 2024 Jul 26;29(7):274. doi: 10.31083/j.fbl2907274. Front Biosci (Landmark Ed). 2024. PMID: 39082350 Free article.
The expression of La-related protein 7 (LARP7), the stimulator of interferon genes (STING) pathway and light chain 3 (LC3) in myocardial tissue was detected by Western blot and immunofluorescence analyses. ...Inhibition of STING or LARP7 expression significantly imp …
The expression of La-related protein 7 (LARP7), the stimulator of interferon genes (STING) pathway and light chain 3 (LC3) in myocard …
Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism.
Hasler D, Meister G, Fischer U. Hasler D, et al. RNA Biol. 2021 Feb;18(2):290-303. doi: 10.1080/15476286.2020.1767952. Epub 2020 Jun 3. RNA Biol. 2021. PMID: 32401147 Free PMC article. Review.
Additionally, recent findings revealed unanticipated roles of LARP7 in the assembly of other RNPs, as well as in the modification, processing and cellular transport of RNA molecules. ...Here, we review the intricate regulatory networks centered on LARP7 and assess h …
Additionally, recent findings revealed unanticipated roles of LARP7 in the assembly of other RNPs, as well as in the modification, pr …
LARP7 overexpression alleviates aortic senescence and atherosclerosis.
Yang P, Wu S, Li Y, Lou Y, Xiong J, Wang Y, Geng Z, Zhang B. Yang P, et al. J Cell Mol Med. 2024 Jun;28(11):e18388. doi: 10.1111/jcmm.18388. J Cell Mol Med. 2024. PMID: 38818612 Free PMC article.
Through RT-PCR and western blotting, we confirmed Larp7 overexpression in the aortas of HFD-fed ApoE(KO); Larp7(tetO) mice. Larp7 overexpression led to increased Sirt1 activity and decreased cellular senescence signals mediated by p53/p65 in the aortas. ...Co …
Through RT-PCR and western blotting, we confirmed Larp7 overexpression in the aortas of HFD-fed ApoE(KO); Larp7(tetO) mice. …
LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis.
Kao TL, Huang YC, Chen YH, Baumann P, Tseng CK. Kao TL, et al. Nat Commun. 2024 Jul 15;15(1):5955. doi: 10.1038/s41467-024-50422-w. Nat Commun. 2024. PMID: 39009594 Free PMC article.
Using biochemical approaches, we find that LARP3 and LARP7/MePCE are involved in the early stage of human telomerase RNA (hTR) and that their binding to RNA is destabilized when the mature form is produced. ...Taken together our data suggest that LARP3 and LARP7/MeP …
Using biochemical approaches, we find that LARP3 and LARP7/MePCE are involved in the early stage of human telomerase RNA (hTR) and th …
LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-kappaB signaling pathway.
Li N, Liu Y. Li N, et al. Allergol Immunopathol (Madr). 2023 Jan 1;51(1):140-145. doi: 10.15586/aei.v51i1.765. eCollection 2023. Allergol Immunopathol (Madr). 2023. PMID: 36617833
Additionally, LARP7 suppressed oxidative stress in the psoriasis-like skin tissues of mice. LARP7 inhibited the activation of the SIRT1/NF-kappaB signaling pathway, and therefore affected the progression of psoriasis. CONCLUSION: LARP7 relieved psoriasis symp …
Additionally, LARP7 suppressed oxidative stress in the psoriasis-like skin tissues of mice. LARP7 inhibited the activation of …
LARP7 is required for sex chromosome silencing during meiosis in mice.
Tando Y, Nonomura A, Ito-Matsuoka Y, Takehara A, Okamura D, Hayashi Y, Matsui Y. Tando Y, et al. PLoS One. 2024 Dec 5;19(12):e0314329. doi: 10.1371/journal.pone.0314329. eCollection 2024. PLoS One. 2024. PMID: 39637191 Free PMC article.
In spermatocytes, LARP7 localizes to the XY body, a compartmentalized chromatin domain on sex chromosomes. ...These results indicate a new functional role for LARP7 in MSCI....
In spermatocytes, LARP7 localizes to the XY body, a compartmentalized chromatin domain on sex chromosomes. ...These results indicate …
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
Wang X, Li ZT, Yan Y, Lin P, Tang W, Hasler D, Meduri R, Li Y, Hua MM, Qi HT, Lin DH, Shi HJ, Hui J, Li J, Li D, Yang JH, Lin J, Meister G, Fischer U, Liu MF. Wang X, et al. Mol Cell. 2020 Mar 5;77(5):999-1013.e6. doi: 10.1016/j.molcel.2020.01.002. Epub 2020 Feb 3. Mol Cell. 2020. PMID: 32017896 Free article.
Mechanistically, LARP7 promotes U6 loading onto box C/D snoRNP, facilitating U6 2'-O-methylation by box C/D snoRNP. Importantly, ablation of LARP7 in the male germline causes defective U6 2'-O-methylation, massive alterations in pre-mRNA splicing, and spermatogenic …
Mechanistically, LARP7 promotes U6 loading onto box C/D snoRNP, facilitating U6 2'-O-methylation by box C/D snoRNP. Importantly, abla …
LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
Yan P, Li Z, Xiong J, Geng Z, Wei W, Zhang Y, Wu G, Zhuang T, Tian X, Liu Z, Liu J, Sun K, Chen F, Zhang Y, Zeng C, Huang Y, Zhang B. Yan P, et al. Cell Rep. 2021 Nov 23;37(8):110038. doi: 10.1016/j.celrep.2021.110038. Cell Rep. 2021. PMID: 34818543 Free article.
Deletion of LARP7 leads to senescent cell accumulation and premature aging in rodent model. Furthermore, we show this ATM-LARP7-SIRT1-p53/p65 senescence axis is active in vascular senescence and atherogenesis, and preventing its activation substantially alleviates s …
Deletion of LARP7 leads to senescent cell accumulation and premature aging in rodent model. Furthermore, we show this ATM-LARP7 …
121 results