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2020 3
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Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo.
Ohol YM, Sun MT, Cutler G, Leger PR, Hu DX, Biannic B, Rana P, Cho C, Jacobson S, Wong ST, Sanchez J, Shah N, Pookot D, Abraham B, Young K, Suthram S, Marshall LA, Bradford D, Kozon N, Han X, Okano A, Maung J, Colas C, Schwarz J, Wustrow D, Brockstedt DG, Kassner PD. Ohol YM, et al. Among authors: leger pr. Mol Cancer Ther. 2020 Oct;19(10):1970-1980. doi: 10.1158/1535-7163.MCT-20-0184. Epub 2020 Aug 11. Mol Cancer Ther. 2020. PMID: 32788207
Isolation, synthesis and bioactivity studies of phomactin terpenoids.
Kuroda Y, Nicacio KJ, da Silva-Jr IA, Leger PR, Chang S, Gubiani JR, Deflon VM, Nagashima N, Rode A, Blackford K, Ferreira AG, Sette LD, Williams DE, Andersen RJ, Jancar S, Berlinck RGS, Sarpong R. Kuroda Y, et al. Among authors: leger pr. Nat Chem. 2018 Sep;10(9):938-945. doi: 10.1038/s41557-018-0084-x. Epub 2018 Jul 30. Nat Chem. 2018. PMID: 30061613
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
Leger PR, Hu DX, Biannic B, Bui M, Han X, Karbarz E, Maung J, Okano A, Osipov M, Shibuya GM, Young K, Higgs C, Abraham B, Bradford D, Cho C, Colas C, Jacobson S, Ohol YM, Pookot D, Rana P, Sanchez J, Shah N, Sun M, Wong S, Brockstedt DG, Kassner PD, Schwarz JB, Wustrow DJ. Leger PR, et al. J Med Chem. 2020 May 28;63(10):5398-5420. doi: 10.1021/acs.jmedchem.0c00245. Epub 2020 May 6. J Med Chem. 2020. PMID: 32302140