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OleD Loki as a Catalyst for Hydroxamate Glycosylation.

Hughes RR, Shaaban KA, Ponomareva LV, Horn J, Zhang C, Zhan CG, Voss SR, Leggas M, Thorson JS. Hughes RR, et al. Among authors: leggas m. Chembiochem. 2020 Apr 1;21(7):952-957. doi: 10.1002/cbic.201900601. Epub 2019 Nov 26. Chembiochem. 2020. PMID: 31621997 Free PMC article.

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Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy.

Liu Y, Eckenrode JM, Zhang Y, Zhang J, Hayden RC, Kyomuhangi A, Ponomareva LV, Cui Z, Rohr J, Tsodikov OV, Van Lanen SG, Shaaban KA, Leggas M, Thorson JS. Liu Y, et al. Among authors: leggas m. J Med Chem. 2020 Nov 25;63(22):14067-14086. doi: 10.1021/acs.jmedchem.0c01526. Epub 2020 Nov 16. J Med Chem. 2020. PMID: 33191745

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Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.

Ye Q, Zhang Y, Cao Y, Wang X, Guo Y, Chen J, Horn J, Ponomareva LV, Chaiswing L, Shaaban KA, Wei Q, Anderson BD, St Clair DK, Zhu H, Leggas M, Thorson JS, She QB. Ye Q, et al. Among authors: leggas m. Cell Chem Biol. 2019 Mar 21;26(3):366-377.e12. doi: 10.1016/j.chembiol.2018.11.013. Epub 2019 Jan 17. Cell Chem Biol. 2019. PMID: 30661989 Free PMC article.

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Bioanalytical method for quantitative determination of mithramycin analogs in mouse plasma by HPLC-QTOF.

Eckenrode JM, Mitra P, Rohr J, Leggas M. Eckenrode JM, et al. Among authors: leggas m. Biomed Chromatogr. 2019 Aug;33(8):e4544. doi: 10.1002/bmc.4544. Epub 2019 May 10. Biomed Chromatogr. 2019. PMID: 30927450

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Pharmacokinetic modeling of the blood-stable camptothecin analog AR-67 in two different formulations.

Liu X, Adane E, Tang F, Leggas M. Liu X, et al. Among authors: leggas m. Biopharm Drug Dispos. 2019 Sep;40(8):265-275. doi: 10.1002/bdd.2199. Epub 2019 Jul 28. Biopharm Drug Dispos. 2019. PMID: 31292985

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Validation of a HPLC/MS method for simultaneous quantification of clonidine, morphine and its metabolites in human plasma.

Tang F, Bada H, Ng CM, Leggas M. Tang F, et al. Among authors: leggas m. Biomed Chromatogr. 2019 Jul;33(7):e4527. doi: 10.1002/bmc.4527. Epub 2019 Mar 20. Biomed Chromatogr. 2019. PMID: 30830964 Free PMC article.

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GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine.

Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin LP. Lee NR, et al. Among authors: leggas m. J Pharmacol Exp Ther. 2019 Nov;371(2):526-543. doi: 10.1124/jpet.119.258699. Epub 2019 Aug 14. J Pharmacol Exp Ther. 2019. PMID: 31413138 Free PMC article.

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Predicting Student Success Using In-Program Monitoring.

Ferrante AB, Lambert J, Leggas M, Black EP. Ferrante AB, et al. Among authors: leggas m. Am J Pharm Educ. 2017 Aug;81(6):111. doi: 10.5688/ajpe816111. Am J Pharm Educ. 2017. PMID: 28970612 Free PMC article.

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Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors.

Tang F, Tsakalozou E, Arnold SM, Ng CM, Leggas M. Tang F, et al. Among authors: leggas m. Invest New Drugs. 2019 Dec;37(6):1218-1230. doi: 10.1007/s10637-019-00744-0. Epub 2019 Feb 28. Invest New Drugs. 2019. PMID: 30820810 Free PMC article. Clinical Trial.

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients With Small-cell Lung Cancer Who Have Progressed on Prior Platinum-based Chemotherapy.

Arnold SM, Chansky K, Baggstrom MQ, Thompson MA, Sanborn RE, Villano JL, Waqar SN, Hamm J, Leggas M, Willis M, Rosales J, Crowley JJ. Arnold SM, et al. Among authors: leggas m. Clin Lung Cancer. 2020 Jul;21(4):357-364.e7. doi: 10.1016/j.cllc.2020.01.006. Epub 2020 Jan 27. Clin Lung Cancer. 2020. PMID: 32173247 Clinical Trial.

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