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High-potency hybrid compounds related to insulin and amphioxus insulin-like peptide.
Chu YC, Burke GT, Gammeltoft S, Chan SJ, Steiner DF, Katsoyannis PG. Chu YC, et al. Among authors: burke gt. Biochemistry. 1994 Nov 8;33(44):13087-92. doi: 10.1021/bi00248a018. Biochemistry. 1994. PMID: 7947713
Amphioxus ILP [8 His] A/insulin B shows activity in these assays greater than that of its parent compound, but not as high as compounds featuring Ile rather than Leu at position A2. In contrast, the parent compound of the present analogues, i.e., amphioxus ILP A/insulin B, …
Amphioxus ILP [8 His] A/insulin B shows activity in these assays greater than that of its parent compound, but not as high as compounds feat …
Steric requirements at position B12 for high biological activity in insulin.
Hu SQ, Burke GT, Schwartz GP, Ferderigos N, Ross JB, Katsoyannis PG. Hu SQ, et al. Among authors: burke gt. Biochemistry. 1993 Mar 16;32(10):2631-5. doi: 10.1021/bi00061a022. Biochemistry. 1993. PMID: 8448120
Substitution of B12 Val with alpha-aminoisobutyric acid (Aib), D-Ala, and Phe led to analogues possessing biological activities, in lipogenesis assays, of 8.5%, 2%, and 0.2%, respectively, relative to that of natural insulin. Inversion of the B11-B12 sequence, -Leu-Val-, l …
Substitution of B12 Val with alpha-aminoisobutyric acid (Aib), D-Ala, and Phe led to analogues possessing biological activities, in lipogene …