Liras JL[au] - Search Results

Year	Number of Results
1996	1
2004	1
2005	3
2006	2
2007	1
2009	1
2012	1
2016	1
2018	1
2019	1
2021	1
2022	1

1

Harnessing Preclinical Data as a Predictive Tool for Human Brain Tissue Targeting.

Patel NC, Feng B, Hou X, West MA, Trapa PE, Sciabola S, Verhoest P, Liras JL, Maurer TS, Wager TT. Patel NC, et al. Among authors: liras jl. ACS Chem Neurosci. 2021 Mar 17;12(6):1007-1017. doi: 10.1021/acschemneuro.0c00807. Epub 2021 Mar 2. ACS Chem Neurosci. 2021. PMID: 33651587

2

Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling.

Wager TT, Liras JL, Mente S, Trapa P. Wager TT, et al. Among authors: liras jl. Expert Opin Drug Metab Toxicol. 2012 May;8(5):531-42. doi: 10.1517/17425255.2012.677028. Epub 2012 Mar 29. Expert Opin Drug Metab Toxicol. 2012. PMID: 22458547 Review.

3

In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.

Trapa PE, Troutman MD, Lau TY, Wager TT, Maurer TS, Patel NC, West MA, Umland JP, Carlo AA, Feng B, Liras JL. Trapa PE, et al. Among authors: liras jl. Drug Metab Dispos. 2019 Apr;47(4):405-411. doi: 10.1124/dmd.118.083279. Epub 2019 Jan 25. Drug Metab Dispos. 2019. PMID: 30683809

4

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.

Humphrey JM, Movsesian M, Am Ende CW, Becker SL, Chappie TA, Jenkinson S, Liras JL, Liras S, Orozco C, Pandit J, Vajdos FF, Vandeput F, Yang E, Menniti FS. Humphrey JM, et al. Among authors: liras jl. J Med Chem. 2018 May 24;61(10):4635-4640. doi: 10.1021/acs.jmedchem.8b00374. Epub 2018 May 10. J Med Chem. 2018. PMID: 29718668

5

Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robertson D, Sperger D, Vaughn-Bowser ML, Waller DM, Yocum SA. Reiter LA, et al. Among authors: liras jl. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5822-6. doi: 10.1016/j.bmcl.2006.08.066. Epub 2006 Aug 30. Bioorg Med Chem Lett. 2006. PMID: 16942871

6

Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration.

Trapa PE, Belova E, Liras JL, Scott DO, Steyn SJ. Trapa PE, et al. Among authors: liras jl. J Pharm Sci. 2016 Feb;105(2):965-971. doi: 10.1016/j.xphs.2015.12.005. J Pharm Sci. 2016. PMID: 26869440

7

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.

Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS, Martinelli GJ, Mitchell PG, Laird ER, Liras JL, Lopresti-Morrow LL, Pandit J, Reilly UD, Robertson D, Vaughn-Bowser ML, Wolf-Gouviea LA, Yocum SA. Freeman-Cook KD, et al. Among authors: liras jl. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6529-34. doi: 10.1016/j.bmcl.2007.09.085. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 17935984

8

Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.

Noe MC, Natarajan V, Snow SL, Mitchell PG, Lopresti-Morrow L, Reeves LM, Yocum SA, Carty TJ, Barberia JA, Sweeney FJ, Liras JL, Vaughn M, Hardink JR, Hawkins JM, Tokar C. Noe MC, et al. Among authors: liras jl. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2808-11. doi: 10.1016/j.bmcl.2005.03.105. Bioorg Med Chem Lett. 2005. PMID: 15911259

9

Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).

Baran SW, Brown PC, Baudy AR, Fitzpatrick SC, Frantz C, Fullerton A, Gan J, Hardwick RN, Hillgren KM, Kopec AK, Liras JL, Mendrick DL, Nagao R, Proctor WR, Ramsden D, Ribeiro AJS, Stresser D, Sung KE, Sura R, Tetsuka K, Tomlinson L, Van Vleet T, Wagoner MP, Wang Q, Arslan SY, Yoder G, Ekert JE. Baran SW, et al. Among authors: liras jl. ALTEX. 2022;39(2). doi: 10.14573/altex.2112203. Epub 2022 Jan 21. ALTEX. 2022. PMID: 35064273 Free article.

10

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

Blagg JA, Noe MC, Wolf-Gouveia LA, Reiter LA, Laird ER, Chang SP, Danley DE, Downs JT, Elliott NC, Eskra JD, Griffiths RJ, Hardink JR, Haugeto AI, Jones CS, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robinson RP, Subramanyam C, Vaughn-Bowser ML, Yocum SA. Blagg JA, et al. Among authors: liras jl. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1807-10. doi: 10.1016/j.bmcl.2005.02.038. Bioorg Med Chem Lett. 2005. PMID: 15780611

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