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Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetič A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale M Jr, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: ljubetic a. Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252. Epub 2022 May 25. Sci Transl Med. 2022. PMID: 35412328 Free PMC article.
Designed Protein Origami.
Drobnak I, Ljubetič A, Gradišar H, Pisanski T, Jerala R. Drobnak I, et al. Among authors: ljubetic a. Adv Exp Med Biol. 2016;940:7-27. doi: 10.1007/978-3-319-39196-0_2. Adv Exp Med Biol. 2016. PMID: 27677507 Review.
SDSL-ESR-based protein structure characterization.
Strancar J, Kavalenka A, Urbancic I, Ljubetic A, Hemminga MA. Strancar J, et al. Among authors: ljubetic a. Eur Biophys J. 2010 Mar;39(4):499-511. doi: 10.1007/s00249-009-0510-5. Epub 2009 Aug 11. Eur Biophys J. 2010. PMID: 19669752 Review.
Designed folding pathway of modular coiled-coil-based proteins.
Aupič J, Strmšek Ž, Lapenta F, Pahovnik D, Pisanski T, Drobnak I, Ljubetič A, Jerala R. Aupič J, et al. Among authors: ljubetic a. Nat Commun. 2021 Feb 11;12(1):940. doi: 10.1038/s41467-021-21185-5. Nat Commun. 2021. PMID: 33574262 Free PMC article.
Advances in design of protein folds and assemblies.
Ljubetič A, Gradišar H, Jerala R. Ljubetič A, et al. Curr Opin Chem Biol. 2017 Oct;40:65-71. doi: 10.1016/j.cbpa.2017.06.020. Epub 2017 Jul 11. Curr Opin Chem Biol. 2017. PMID: 28709120 Review.
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks.
Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetič A, Loshbaugh AL, Maguire J, Moretti R, Mulligan VK, Nance ML, Nguyen PT, Ó Conchúir S, Roy Burman SS, Samanta R, Smith ST, Teets F, Tiemann JKS, Watkins A, Woods H, Yachnin BJ, Bahl CD, Bailey-Kellogg C, Baker D, Das R, DiMaio F, Khare SD, Kortemme T, Labonte JW, Lindorff-Larsen K, Meiler J, Schief W, Schueler-Furman O, Siegel JB, Stein A, Yarov-Yarovoy V, Kuhlman B, Leaver-Fay A, Gront D, Gray JJ, Bonneau R. Koehler Leman J, et al. Among authors: ljubetic a. Nat Commun. 2021 Nov 29;12(1):6947. doi: 10.1038/s41467-021-27222-7. Nat Commun. 2021. PMID: 34845212 Free PMC article.
Multivalent designed proteins protect against SARS-CoV-2 variants of concern.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger-Gericke A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken S, Ljubetič A, Edman N, Ueda G, Chow C, Addetia A, Panpradist N, Gale M Jr, Freedman BS, Lutz BR, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: ljubetic a. bioRxiv. 2021 Jul 7:2021.07.07.451375. doi: 10.1101/2021.07.07.451375. Preprint. bioRxiv. 2021. PMID: 34268509 Free PMC article. Updated.
18 results