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Polyploidy in Tissue Repair and Regeneration.

Bailey EC, Kobielski S, Park J, Losick VP. Bailey EC, et al. Among authors: losick vp. Cold Spring Harb Perspect Biol. 2021 Oct 1;13(10):a040881. doi: 10.1101/cshperspect.a040881. Cold Spring Harb Perspect Biol. 2021. PMID: 34187807 Review.

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Solving the Polyploid Mystery in Health and Disease.

Gjelsvik KJ, Besen-McNally R, Losick VP. Gjelsvik KJ, et al. Among authors: losick vp. Trends Genet. 2019 Jan;35(1):6-14. doi: 10.1016/j.tig.2018.10.005. Epub 2018 Nov 21. Trends Genet. 2019. PMID: 30470486 Free PMC article. Review.

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Wound-induced polyploidization is dependent on Integrin-Yki signaling.

Besen-McNally R, Gjelsvik KJ, Losick VP. Besen-McNally R, et al. Among authors: losick vp. Biol Open. 2021 Jan 25;10(1):bio055996. doi: 10.1242/bio.055996. Biol Open. 2021. PMID: 33355119 Free PMC article.

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Wound-Induced Polyploidy Is Required for Tissue Repair.

Losick VP. Losick VP. Adv Wound Care (New Rochelle). 2016 Jun 1;5(6):271-278. doi: 10.1089/wound.2014.0545. Adv Wound Care (New Rochelle). 2016. PMID: 27274437 Free PMC article. Review.

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A Drosophila Model to Study Wound-induced Polyploidization.

Bailey EC, Dehn AS, Gjelsvik KJ, Besen-McNally R, Losick VP. Bailey EC, et al. Among authors: losick vp. J Vis Exp. 2020 Jun 9;(160):10.3791/61252. doi: 10.3791/61252. J Vis Exp. 2020. PMID: 32597839 Free PMC article.

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The endocycle restores tissue tension in the Drosophila abdomen post wound repair.

Losick VP, Duhaime LG. Losick VP, et al. Cell Rep. 2021 Oct 12;37(2):109827. doi: 10.1016/j.celrep.2021.109827. Cell Rep. 2021. PMID: 34644579 Free PMC article.

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Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.

Losick VP, Morris LX, Fox DT, Spradling A. Losick VP, et al. Dev Cell. 2011 Jul 19;21(1):159-71. doi: 10.1016/j.devcel.2011.06.018. Dev Cell. 2011. PMID: 21763616 Free PMC article. Review.

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Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage.

Grendler J, Lowgren S, Mills M, Losick VP. Grendler J, et al. Among authors: losick vp. Development. 2019 Aug 2;146(15):dev173005. doi: 10.1242/dev.173005. Development. 2019. PMID: 31315896 Free PMC article.

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Binucleation ramps up gene expression meeting the physiological demands of an organism.

Dehn AS, Losick VP. Dehn AS, et al. Among authors: losick vp. PLoS Biol. 2022 May 25;20(5):e3001639. doi: 10.1371/journal.pbio.3001639. eCollection 2022 May. PLoS Biol. 2022. PMID: 35613076 Free PMC article.

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Wound-Induced Polyploidization: Regulation by Hippo and JNK Signaling and Conservation in Mammals.

Losick VP, Jun AS, Spradling AC. Losick VP, et al. PLoS One. 2016 Mar 9;11(3):e0151251. doi: 10.1371/journal.pone.0151251. eCollection 2016. PLoS One. 2016. PMID: 26958853 Free PMC article.

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