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Targeting ERK3/MK5 complex for treatment of obesity and diabetes.
Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera JT, Karwen T, Noh M, Löffler MC, Romero-Becerra R, Torres JL, Marcos M, Sabio G, Wojda U, Sumara G. Loza-Valdes A, et al. Biochem Biophys Res Commun. 2022 Jul 5;612:119-125. doi: 10.1016/j.bbrc.2022.04.070. Epub 2022 Apr 27. Biochem Biophys Res Commun. 2022. PMID: 35523049 Free article.
Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.
Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G. Trujillo-Viera J, et al. Among authors: loza valdes a. EMBO Mol Med. 2021 May 7;13(5):e13548. doi: 10.15252/emmm.202013548. Epub 2021 May 5. EMBO Mol Med. 2021. PMID: 33949105 Free PMC article.
Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity.
Löffler MC, Mayer AE, Trujillo Viera J, Loza Valdes A, El-Merahbi R, Ade CP, Karwen T, Schmitz W, Slotta A, Erk M, Janaki-Raman S, Matesanz N, Torres JL, Marcos M, Sabio G, Eilers M, Schulze A, Sumara G. Löffler MC, et al. Among authors: loza valdes a. EMBO J. 2018 Nov 15;37(22):e99182. doi: 10.15252/embj.201899182. Epub 2018 Nov 2. EMBO J. 2018. PMID: 30389661 Free PMC article.
Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice.
González-Granillo M, Steffensen KR, Granados O, Torres N, Korach-André M, Ortíz V, Aguilar-Salinas C, Jakobsson T, Díaz-Villaseñor A, Loza-Valdes A, Hernandez-Pando R, Gustafsson JÅ, Tovar AR. González-Granillo M, et al. Among authors: loza valdes a. Diabetologia. 2012 Sep;55(9):2469-78. doi: 10.1007/s00125-012-2599-9. Epub 2012 Jun 29. Diabetologia. 2012. PMID: 22739758