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Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.

Ivashchenko CY, Pipes GC, Lozinskaya IM, Lin Z, Xiaoping X, Needle S, Grygielko ET, Hu E, Toomey JR, Lepore JJ, Willette RN. Ivashchenko CY, et al. Among authors: lozinskaya im. Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H913-22. doi: 10.1152/ajpheart.00819.2012. Epub 2013 Jul 5. Am J Physiol Heart Circ Physiol. 2013. PMID: 23832699 Free article.

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An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN. Thorneloe KS, et al. Among authors: lozinskaya i. Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276. Sci Transl Med. 2012. PMID: 23136043 Free article.

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The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.

Washburn DG, Holt DA, Dodson J, McAtee JJ, Terrell LR, Barton L, Manns S, Waszkiewicz A, Pritchard C, Gillie DJ, Morrow DM, Davenport EA, Lozinskaya IM, Guss J, Basilla JB, Negron LK, Klein M, Willette RN, Fries RE, Jensen TC, Xu X, Schnackenberg CG, Marino JP Jr. Washburn DG, et al. Among authors: lozinskaya im. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84. doi: 10.1016/j.bmcl.2013.06.047. Epub 2013 Jun 26. Bioorg Med Chem Lett. 2013. PMID: 23886683

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Ramipril treatment alters Ca(2+) and K(+) channels in small mesenteric arteries from Wistar-Kyoto and spontaneously hypertensive rats.

Cox RH, Lozinskaya I, Matsuda K, Dietz NJ. Cox RH, et al. Among authors: lozinskaya i. Am J Hypertens. 2002 Oct;15(10 Pt 1):879-90. Am J Hypertens. 2002. PMID: 12372675

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Characterizing the role of Thr352 in the inhibition of the large conductance Ca2+-activated K+ channels by 1-[1-hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone.

Gordon E, Semus SF, Lozinskaya IM, Lin Z, Xu X. Gordon E, et al. Among authors: lozinskaya im. J Pharmacol Exp Ther. 2010 Aug;334(2):402-9. doi: 10.1124/jpet.110.166017. Epub 2010 Apr 29. J Pharmacol Exp Ther. 2010. PMID: 20430843 Free article.

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Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells.

Xu X, Gordon E, Lin Z, Lozinskaya IM, Chen Y, Thorneloe KS. Xu X, et al. Among authors: lozinskaya im. Channels (Austin). 2009 May-Jun;3(3):156-60. doi: 10.4161/chan.3.3.8555. Epub 2009 May 24. Channels (Austin). 2009. PMID: 19411839

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Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.

Zeng H, Lozinskaya IM, Lin Z, Willette RN, Brooks DP, Xu X. Zeng H, et al. Among authors: lozinskaya im. J Pharmacol Exp Ther. 2006 Nov;319(2):957-62. doi: 10.1124/jpet.106.110593. Epub 2006 Aug 23. J Pharmacol Exp Ther. 2006. PMID: 16928897

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1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone, a potent and highly selective small molecule blocker of the large-conductance voltage-gated and calcium-dependent K+ channel.

Zeng H, Gordon E, Lin Z, Lozinskaya IM, Willette RN, Xu X. Zeng H, et al. Among authors: lozinskaya im. J Pharmacol Exp Ther. 2008 Oct;327(1):168-77. doi: 10.1124/jpet.108.139733. Epub 2008 Jun 30. J Pharmacol Exp Ther. 2008. PMID: 18591221

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Acetic acid opens large-conductance Ca2+-activated K+ channels in guinea pig detrusor smooth muscle cells.

Ghatta S, Lozinskaya I, Lin Z, Gordon E, Willette RN, Brooks DP, Xu X. Ghatta S, et al. Among authors: lozinskaya i. Eur J Pharmacol. 2007 Jun 1;563(1-3):203-8. doi: 10.1016/j.ejphar.2007.02.037. Epub 2007 Feb 27. Eur J Pharmacol. 2007. PMID: 17382925

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2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.

Gordon E, Lozinskaya IM, Lin Z, Semus SF, Blaney FE, Willette RN, Xu X. Gordon E, et al. Among authors: lozinskaya im. Mol Pharmacol. 2008 Mar;73(3):639-51. doi: 10.1124/mol.107.041152. Epub 2007 Nov 27. Mol Pharmacol. 2008. PMID: 18042732

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