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Page 1
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8(+) T cell infiltration and functional transition.
Yu A, Hu J, Fu L, Huang G, Deng D, Zhang M, Wang Y, Shu G, Jing L, Li H, Chen X, Yang T, Wei J, Chen Z, Zu X, Luo J. Yu A, et al. J Immunother Cancer. 2023 Oct;11(10):e007230. doi: 10.1136/jitc-2023-007230. J Immunother Cancer. 2023. PMID: 37802603 Free PMC article.
Preclinically, LRFN2 knockdown significantly enhanced the efficacy of ICI therapy. Clinically, LRFN2 can predict immunotherapy responses in real-world and public immunotherapy cohorts. ...CONCLUSIONS: Thus, LRFN2 represents a new target that can be combined w …
Preclinically, LRFN2 knockdown significantly enhanced the efficacy of ICI therapy. Clinically, LRFN2 can predict immunotherapy …
LRFN2 binding to NMDAR inhibits the progress of ESCC via regulating the Wnt/beta-Catenin and NF-kappaB signaling pathway.
Zhou Y, Xu L, Wang J, Ge B, Wang Q, Wang T, Liu C, Wei B, Wang Q, Gao Y. Zhou Y, et al. Cancer Sci. 2022 Oct;113(10):3566-3578. doi: 10.1111/cas.15510. Epub 2022 Aug 8. Cancer Sci. 2022. PMID: 35879265 Free PMC article.
Genetic studies suggest that mutations in LRFN2 are associated with various cancers. However, the role and mechanism of LRFN2 in the progression of ESCC have not been elucidated. ...Low LRFN2 expression was an adverse prognostic factor in patients with ESCC. …
Genetic studies suggest that mutations in LRFN2 are associated with various cancers. However, the role and mechanism of LRFN2 …
Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2.
McMillan KJ, Banks PJ, Hellel FL, Carmichael RE, Clairfeuille T, Evans AJ, Heesom KJ, Lewis P, Collins BM, Bashir ZI, Henley JM, Wilkinson KA, Cullen PJ. McMillan KJ, et al. Elife. 2021 Jul 12;10:e59432. doi: 10.7554/eLife.59432. Elife. 2021. PMID: 34251337 Free PMC article.
Focusing on the synaptic adhesion molecule LRFN2, we established that SNX27 binds to LRFN2 and regulates its endosomal sorting. Furthermore, LRFN2 associates with AMPA receptors and knockdown of LRFN2 results in decreased surface AMPA receptor expressi …
Focusing on the synaptic adhesion molecule LRFN2, we established that SNX27 binds to LRFN2 and regulates its endosomal sorting …
Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response.
Li Y, Kim R, Cho YS, Song WS, Kim D, Kim K, Roh JD, Chung C, Park H, Yang E, Kim SJ, Ko J, Kim H, Kim MH, Bae YC, Kim E. Li Y, et al. J Neurosci. 2018 Jun 27;38(26):5872-5887. doi: 10.1523/JNEUROSCI.3321-17.2018. Epub 2018 May 24. J Neurosci. 2018. PMID: 29798891 Free PMC article.
Here, we found that mice lacking SALM1/LRFN2 (Lrfn2(-/-) mice) show a normal density of excitatory synapses but altered excitatory synaptic function, including enhanced NMDAR-dependent synaptic transmission but suppressed NMDAR-dependent synaptic plasticity in the h …
Here, we found that mice lacking SALM1/LRFN2 (Lrfn2(-/-) mice) show a normal density of excitatory synapses but altered excita …
LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir.
Shah R, Sharma V, Singh H, Sharma I, Bhat GA, Shah IA, Iqbal B, Rafiq R, Nissa N, Muzaffar M, Rasool MT, Lone GN, Kaul S, Lone MM, Rai E, Dar NA, Sharma S. Shah R, et al. J Cancer Res Ther. 2020 Dec;16(Supplement):S156-S159. doi: 10.4103/jcrt.JCRT_613_19. J Cancer Res Ther. 2020. PMID: 32880595 Free article.
BACKGROUND: Leucine-rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophageal cancer in a genome-wide association study in an Asian population. ...RESULTS: Variant rs2494938 was observed to be significantly associa …
BACKGROUND: Leucine-rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophag …
Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.
Morimura N, Yasuda H, Yamaguchi K, Katayama KI, Hatayama M, Tomioka NH, Odagawa M, Kamiya A, Iwayama Y, Maekawa M, Nakamura K, Matsuzaki H, Tsujii M, Yamada K, Yoshikawa T, Aruga J. Morimura N, et al. Nat Commun. 2017 Jun 12;8:15800. doi: 10.1038/ncomms15800. Nat Commun. 2017. PMID: 28604739 Free PMC article.
Lrfn2/SALM1 is a PSD-95-interacting synapse adhesion molecule, and human LRFN2 is associated with learning disabilities. ...Together, these findings indicate that Lrfn2/LRFN2 serve as core components of excitatory synapse maturation and maintenance, an …
Lrfn2/SALM1 is a PSD-95-interacting synapse adhesion molecule, and human LRFN2 is associated with learning disabilities. ...To …
Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice.
Maekawa R, Muto H, Hatayama M, Aruga J. Maekawa R, et al. PLoS One. 2021 Jan 22;16(1):e0245624. doi: 10.1371/journal.pone.0245624. eCollection 2021. PLoS One. 2021. PMID: 33481887 Free PMC article.
LRFN2 encodes a synaptic adhesion-like molecule that physically interacts with N-methyl-D-aspartate (NMDA) receptor 1 and its scaffold proteins. ...In mature Lrfn2 KO male mice, peripheral blood tests showed multilineage abnormalities, including normocytic erythrocy …
LRFN2 encodes a synaptic adhesion-like molecule that physically interacts with N-methyl-D-aspartate (NMDA) receptor 1 and its scaffol …
Genetic variant rs2494938 of LRFN2 gene is associated with non-small cell lung cancer risk in North-Indian population.
Bhat GR, Verma S, Bhat A, Shah R, Sethi I, Dar KA, Abrol D, Bhat A, Raina R, Kumar R. Bhat GR, et al. 3 Biotech. 2020 Sep;10(9):410. doi: 10.1007/s13205-020-02403-1. Epub 2020 Aug 28. 3 Biotech. 2020. PMID: 32904533 Free PMC article.
Various Genome-wide association studies (GWAS) have reported the association of variant rs2494938 with lung cancer. However, genetic association of LRFN2 genetic variation with non-small cell lung cancer (NSCLC) in North Indian population remained unexplored. ...These resu …
Various Genome-wide association studies (GWAS) have reported the association of variant rs2494938 with lung cancer. However, genetic associa …
Genetic variants of DNAH11 and LRFN2 genes and their association with ovarian and breast cancer.
Verma S, Bakshi D, Sharma V, Sharma I, Shah R, Bhat A, Bhat GR, Sharma B, Wakhloo A, Kaul S, Heer V, Bhat A, Abrol D, Verma V, Kumar R. Verma S, et al. Int J Gynaecol Obstet. 2020 Jan;148(1):118-122. doi: 10.1002/ijgo.12997. Epub 2019 Oct 31. Int J Gynaecol Obstet. 2020. PMID: 31605628
OBJECTIVE: To investigate the association of newly identified genetic variants G>A (rs2285947) of the DNAH11 gene and G>A (rs2494938) of the LRFN2 gene with ovarian and breast cancers in women belonging to Jammu and Kashmir state, where the prevalence of ovarian and …
OBJECTIVE: To investigate the association of newly identified genetic variants G>A (rs2285947) of the DNAH11 gene and G>A (rs2494938) …
Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles.
Kang RB, Li Y, Rosselot C, Zhang T, Siddiq M, Rajbhandari P, Stewart AF, Scott DK, Garcia-Ocana A, Lu G. Kang RB, et al. Genome Med. 2023 May 1;15(1):30. doi: 10.1186/s13073-023-01179-2. Genome Med. 2023. PMID: 37127706 Free PMC article.
RESULTS: First, snRNA-seq analysis shows that the top four differentially and selectively expressed genes in human islet endocrine cells in vitro and in vivo are not the canonical genes but a new set of non-canonical gene markers including ZNF385D, TRPM3, LRFN2, PLUT (beta …
RESULTS: First, snRNA-seq analysis shows that the top four differentially and selectively expressed genes in human islet endocrine cells in …
30 results