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490 results

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Page 1
Structures of LRP2 reveal a molecular machine for endocytosis.
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L. Beenken A, et al. Cell. 2023 Feb 16;186(4):821-836.e13. doi: 10.1016/j.cell.2023.01.016. Epub 2023 Feb 6. Cell. 2023. PMID: 36750096 Free PMC article.
Here, we report high-resolution cryoelectron microscopy structures of LRP2 isolated from mouse kidney, at extracellular and endosomal pH. The structures reveal LRP2 to be a molecular machine that adopts a conformation for ligand binding at the cell surface and for l …
Here, we report high-resolution cryoelectron microscopy structures of LRP2 isolated from mouse kidney, at extracellular and endosomal …
Anti-LRP2 Nephropathy.
Gallan AJ, Garg A, Collins AB, Beck LH Jr, Trivin-Avillach C, Henriksen KJ, Chang A. Gallan AJ, et al. Kidney Int Rep. 2020 Sep 12;5(12):2365-2370. doi: 10.1016/j.ekir.2020.09.011. eCollection 2020 Dec. Kidney Int Rep. 2020. PMID: 33305133 Free PMC article. No abstract available.
Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.
Willnow TE, Christ A. Willnow TE, et al. Pflugers Arch. 2017 Aug;469(7-8):907-916. doi: 10.1007/s00424-017-1992-0. Epub 2017 May 11. Pflugers Arch. 2017. PMID: 28497274 Review.
Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. ...
Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. ...
LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.
Christ A, Herzog K, Willnow TE. Christ A, et al. Dev Dyn. 2016 May;245(5):569-79. doi: 10.1002/dvdy.24394. Epub 2016 Mar 4. Dev Dyn. 2016. PMID: 26872844 Free article. Review.
Here, we discuss recent findings on the LDL receptor-related protein 2 (LRP2), an exemplary HH binding protein that modulates sonic hedgehog activities in stem and progenitor cell niches in embryonic and adult tissues. LRP2 functions are crucial for developmental pr …
Here, we discuss recent findings on the LDL receptor-related protein 2 (LRP2), an exemplary HH binding protein that modulates sonic h …
Variants of LRP2, encoding a multifunctional cell-surface endocytic receptor, associated with hearing loss and retinal dystrophy.
Faridi R, Yousaf R, Gu S, Inagaki S, Turriff AE, Pelstring K, Guan B, Naik A, Griffith AJ, Adadey SM, Aboagye ET, Awandare GA, Morell RJ, Tsilou E, Noyes AG, Sulmonte LAG, Wonkam A, Schrauwen I, Leal SM, Azaiez H, Brewer CC, Riazuddin S, Hufnagel RB, Hoa M, Zein WM, de Dios JK, Friedman TB. Faridi R, et al. Clin Genet. 2023 Jun;103(6):699-703. doi: 10.1111/cge.14312. Epub 2023 Mar 13. Clin Genet. 2023. PMID: 36807241 Free PMC article.
The proband of Family 1 was found to be compound heterozygous for NM_004525.3: LRP2: c.5005A > G, p.(Asn1669Asp) and c.149C > G, p.(Thr50Ser). In Family 2, two sisters were found to be compound heterozygous for LRP2 variants, p....In Family 3, the proband is c …
The proband of Family 1 was found to be compound heterozygous for NM_004525.3: LRP2: c.5005A > G, p.(Asn1669Asp) and c.149C > G …
LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.
Bunatyan L, Margineanu A, Boutin C, Montcouquiol M, Bachmann S, Ilsø Christensen E, Willnow TE, Christ A. Bunatyan L, et al. Cell Tissue Res. 2023 May;392(2):535-551. doi: 10.1007/s00441-023-03757-7. Epub 2023 Feb 11. Cell Tissue Res. 2023. PMID: 36764939 Free PMC article.
Here, we identified the endocytic receptor LRP2 as regulator of PCP component trafficking in ependyma, a multi-ciliated cell type that is involved in facilitating flow of the cerebrospinal fluid in the brain ventricular system. Lack of receptor expression in gene-targeted …
Here, we identified the endocytic receptor LRP2 as regulator of PCP component trafficking in ependyma, a multi-ciliated cell type tha …
Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
Sandin ES, Folberth J, Müller-Fielitz H, Pietrzik CU, Herold E, Willnow TE, Pfluger PT, Nogueiras R, Prevot V, Krey T, Schwaninger M. Sandin ES, et al. Int J Mol Sci. 2021 May 8;22(9):4998. doi: 10.3390/ijms22094998. Int J Mol Sci. 2021. PMID: 34066779 Free PMC article.
The LRP inhibitor RAP did not affect leptin transport, arguing against a role of LRP2. In line with this, the selective deletion of LRP2 in brain endothelial cells and epithelial cells of the choroid plexus did not influence bodyweight, body composition, food intake …
The LRP inhibitor RAP did not affect leptin transport, arguing against a role of LRP2. In line with this, the selective deletion of …
LRP2 mediates folate uptake in the developing neural tube.
Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A. Kur E, et al. J Cell Sci. 2014 May 15;127(Pt 10):2261-8. doi: 10.1242/jcs.140145. Epub 2014 Mar 17. J Cell Sci. 2014. PMID: 24639464
The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2) is a multifunctional cell-surface receptor expressed in the embryonic neuroepithelium. ...Consequently, folate concentrations are significantly reduced in Lrp2(-/-) embryos compared with control lit …
The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2) is a multifunctional cell-surface receptor expressed in the embry …
LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.
Christ A, Marczenke M, Willnow TE. Christ A, et al. Hum Mol Genet. 2020 Nov 25;29(19):3183-3196. doi: 10.1093/hmg/ddaa200. Hum Mol Genet. 2020. PMID: 32901292 Free PMC article.
Recently, genetic screens in humans and in mouse models have identified mutations in LRP2, a multi-ligand receptor, as a novel cause of a common arterial trunk, a severe form of outflow tract (OFT) defect. Yet, the underlying mechanism why the morphogen receptor LRP2 …
Recently, genetic screens in humans and in mouse models have identified mutations in LRP2, a multi-ligand receptor, as a novel cause …
Targeting inhibition of prognosis-related lipid metabolism genes including CYP19A1 enhances immunotherapeutic response in colon cancer.
Liu L, Mo M, Chen X, Chao D, Zhang Y, Chen X, Wang Y, Zhang N, He N, Yuan X, Chen H, Yang J. Liu L, et al. J Exp Clin Cancer Res. 2023 Apr 13;42(1):85. doi: 10.1186/s13046-023-02647-8. J Exp Clin Cancer Res. 2023. PMID: 37055842 Free PMC article.
RESULTS: Six LMGs including CYP19A1, ALOXE3, FABP4, LRP2, SLCO1A2 and PPARGC1A were selected to establish the LMrisk. The LMrisk was positively correlated with the abundance of macrophages, carcinoma-associated fibroblasts (CAFs), endothelial cells and the levels of biomar …
RESULTS: Six LMGs including CYP19A1, ALOXE3, FABP4, LRP2, SLCO1A2 and PPARGC1A were selected to establish the LMrisk. The LMrisk was …
490 results