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Page 1
LST1: A multifunctional gene encoded in the MHC class III region.
Weidle UH, Rohwedder I, Birzele F, Weiss EH, Schiller C. Weidle UH, et al. Immunobiology. 2018 Nov;223(11):699-708. doi: 10.1016/j.imbio.2018.07.018. Epub 2018 Jul 17. Immunobiology. 2018. PMID: 30055863 Review.
The LST1 gene is located in the MHC class III cluster between the MHC class I and II regions. ...We focus on LST1 expression in inflammation and discuss known correlations with autoimmune diseases and cancer. ...
The LST1 gene is located in the MHC class III cluster between the MHC class I and II regions. ...We focus on LST1 expression i …
Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.
Fabisik M, Tureckova J, Pavliuchenko N, Kralova J, Balounova J, Vicikova K, Skopcova T, Spoutil F, Pokorna J, Angelisova P, Malissen B, Prochazka J, Sedlacek R, Brdicka T. Fabisik M, et al. Front Immunol. 2021 Apr 27;12:618332. doi: 10.3389/fimmu.2021.618332. eCollection 2021. Front Immunol. 2021. PMID: 33986741 Free PMC article.
Moreover, LST1-deficient mice show significant level of resistance to dextran sodium sulphate (DSS) induced acute colitis, a model of inflammatory bowel disease. These data demonstrate that LST1 regulates leukocyte abundance in lymphoid organs and inflammatory respo …
Moreover, LST1-deficient mice show significant level of resistance to dextran sodium sulphate (DSS) induced acute colitis, a model of …
LST1: a gene with extensive alternative splicing and immunomodulatory function.
Rollinger-Holzinger I, Eibl B, Pauly M, Griesser U, Hentges F, Auer B, Pall G, Schratzberger P, Niederwieser D, Weiss EH, Zwierzina H. Rollinger-Holzinger I, et al. J Immunol. 2000 Mar 15;164(6):3169-76. doi: 10.4049/jimmunol.164.6.3169. J Immunol. 2000. PMID: 10706707
We identified 7 different LST1 splice variants in PBMC; thus, 14 LST1 splice variants (LST1/A-LST1/N) have been detected in various cell types. ...In contrast, the alternative transmembrane variant LST1/A, the extracellular domain of which shows …
We identified 7 different LST1 splice variants in PBMC; thus, 14 LST1 splice variants (LST1/A-LST1/N) have been …
Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.
Leist SR, Kollmus H, Hatesuer B, Lambertz RL, Schughart K. Leist SR, et al. Virol J. 2016 Jan 27;13:17. doi: 10.1186/s12985-016-0471-0. Virol J. 2016. PMID: 26817701 Free PMC article.
Several studies have proposed that LST1 plays a role in the immune response to inflammatory diseases in humans and has additional immune-regulatory functions. Here, we evaluated the relevance of LST1 for the host response to influenza A infection in B6-Lst1 ( …
Several studies have proposed that LST1 plays a role in the immune response to inflammatory diseases in humans and has additional imm …
LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation.
Schiller C, Diakopoulos KN, Rohwedder I, Kremmer E, von Toerne C, Ueffing M, Weidle UH, Ohno H, Weiss EH. Schiller C, et al. J Cell Sci. 2013 Feb 1;126(Pt 3):767-77. doi: 10.1242/jcs.114033. Epub 2012 Dec 13. J Cell Sci. 2013. PMID: 23239025
Mechanistically, we found that LST1 induces nanotube formation by recruiting the small GTPase RalA to the plasma membrane and promoting its interaction with the exocyst complex. Furthermore, we determined that LST1 recruits the actin-crosslinking protein filamin to …
Mechanistically, we found that LST1 induces nanotube formation by recruiting the small GTPase RalA to the plasma membrane and promoti …
LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum.
Roberg KJ, Crotwell M, Espenshade P, Gimeno R, Kaiser CA. Roberg KJ, et al. J Cell Biol. 1999 May 17;145(4):659-72. doi: 10.1083/jcb.145.4.659. J Cell Biol. 1999. PMID: 10330397 Free PMC article.
We identified mutations in ten genes, designated LST (lethal with sec-thirteen), that were lethal in combination with the COPII mutation sec13-1. LST1 showed synthetic-lethal interactions with the complete set of COPII genes, indicating that LST1 encodes a new COPII …
We identified mutations in ten genes, designated LST (lethal with sec-thirteen), that were lethal in combination with the COPII mutation sec …
LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection.
Mulcahy H, O'Rourke KP, Adams C, Molloy MG, O'Gara F. Mulcahy H, et al. Immunogenetics. 2006 Jan;57(12):893-903. doi: 10.1007/s00251-005-0057-2. Epub 2005 Dec 17. Immunogenetics. 2006. PMID: 16362817
The LST1 gene undergoes extensive alternative splicing, giving rise to both membrane-bound (encoded by exon 3) and soluble isoforms. ...These findings suggest that NCR3 and soluble isoforms of LST1 may play a role in inflammatory and infectious diseases....
The LST1 gene undergoes extensive alternative splicing, giving rise to both membrane-bound (encoded by exon 3) and soluble isoforms. …
Rat monoclonal antibodies specific for LST1 proteins.
Schiller C, Nitschké MJ, Seidl A, Kremmer E, Weiss EH. Schiller C, et al. Hybridoma (Larchmt). 2009 Aug;28(4):281-6. doi: 10.1089/hyb.2009.0021. Hybridoma (Larchmt). 2009. PMID: 19663701 Free article.
Here we describe the generation and characterization of the first monoclonal antibodies against LST1. Two hybridoma lines secreting monoclonal antibodies designated 7E2 and 8D12 were established. The 7E2 antibody detects recombinant and endogenous LST1 by Western bl …
Here we describe the generation and characterization of the first monoclonal antibodies against LST1. Two hybridoma lines secreting m …
LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.
Draber P, Stepanek O, Hrdinka M, Drobek A, Chmatal L, Mala L, Ormsby T, Angelisova P, Horejsi V, Brdicka T. Draber P, et al. J Biol Chem. 2012 Jun 29;287(27):22812-21. doi: 10.1074/jbc.M112.339143. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22589543 Free PMC article.
They participate in the regulation of various signaling pathways by recruiting other proteins to the proximity of cellular membranes where the signaling is often initiated and propagated. In this work, we show that LST1/A, an incompletely characterized protein encoded by M …
They participate in the regulation of various signaling pathways by recruiting other proteins to the proximity of cellular membranes where t …
An upstream open reading frame regulates LST1 expression during monocyte differentiation.
Schiller C, Nowak C, Diakopoulos KN, Weidle UH, Weiss EH. Schiller C, et al. PLoS One. 2014 May 9;9(5):e96245. doi: 10.1371/journal.pone.0096245. eCollection 2014. PLoS One. 2014. PMID: 24816991 Free PMC article.
The main objective of the present study was to assess whether uORFs regulate the expression of the MHC class III gene LST1. We report that expression of LST1 is tightly regulated by alternative transcription initiation and the presence of an uORF in the 5'-UTR of tr …
The main objective of the present study was to assess whether uORFs regulate the expression of the MHC class III gene LST1. We report …
138 results