Intracellular delivery of virus-like particles using a sheddable linker.
Hagge LM, Shahrivarkevishahi A, Al-Kharji NM, Chen Z, Brohlin OR, Trashi I, Tumac A, C Herbert F, Adlooru AV, Lee H, Firouzi HR, Cornelius SA, De Nisco NJ, Gassensmith JJ.
Hagge LM, et al.
J Mater Chem B. 2023 Aug 2;11(30):7126-7133. doi: 10.1039/d3tb00696d.
J Mater Chem B. 2023.
PMID: 37401235
As a proof of concept, we encapsulated luciferase-targeted siRNA (siLuc) inside the VLP decorated with the maleimide-TPP (M-TPP) linker. We observed enhanced luminescence silencing in luciferase-expressing HeLa cells using our sheddable TPP linker compared to control VLPs. …
As a proof of concept, we encapsulated luciferase-targeted siRNA (siLuc) inside the VLP decorated with the maleimide-TPP (M-TPP) link …