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114 results

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Page 1
Did you mean m alam (2,188 results)?
Neutrophil cell surface receptors and their intracellular signal transduction pathways.
Futosi K, Fodor S, Mócsai A. Futosi K, et al. Int Immunopharmacol. 2013 Nov;17(3):638-50. doi: 10.1016/j.intimp.2013.06.034. Epub 2013 Aug 30. Int Immunopharmacol. 2013. PMID: 23994464 Free PMC article. Review.
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue damage during autoimmune and inflammatory diseases. ...The various cell surface receptors trigger very diverse signal …
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also …
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. Feucht J, et al. Nat Med. 2019 Jan;25(1):82-88. doi: 10.1038/s41591-018-0290-5. Epub 2018 Dec 17. Nat Med. 2019. PMID: 30559421 Free PMC article.
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and differentiation. Here, we show that CARs encoding a single immunoreceptor tyrosine-based activation motif …
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and …
CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas.
Gang M, Marin ND, Wong P, Neal CC, Marsala L, Foster M, Schappe T, Meng W, Tran J, Schaettler M, Davila M, Gao F, Cashen AF, Bartlett NL, Mehta-Shah N, Kahl BS, Kim MY, Cooper ML, DiPersio JF, Berrien-Elliott MM, Fehniger TA. Gang M, et al. Blood. 2020 Nov 12;136(20):2308-2318. doi: 10.1182/blood.2020006619. Blood. 2020. PMID: 32614951 Free PMC article.
Cytokine-induced memory-like (ML) NK cells differentiate after activation with interleukin-12 (IL-12), IL-15, and IL-18, exhibit potent antitumor responses, and safely induce complete remissions in patients with leukemia. ...The 19-CAR and ML responses were synergistic and …
Cytokine-induced memory-like (ML) NK cells differentiate after activation with interleukin-12 (IL-12), IL-15, and IL-18, exhibit pote …
L-Methioninium picrate.
Ghazaryan VV, Zakharov BA, Boldyreva EV, Petrosyan AM. Ghazaryan VV, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2015 May 5;142:344-9. doi: 10.1016/j.saa.2015.02.036. Epub 2015 Feb 14. Spectrochim Acta A Mol Biomol Spectrosc. 2015. PMID: 25710892
L-tryptophan L-tryptophanium chloride.
Ghazaryan VV, Fleck M, Petrosyan AM. Ghazaryan VV, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt B:743-50. doi: 10.1016/j.saa.2014.09.090. Epub 2014 Sep 30. Spectrochim Acta A Mol Biomol Spectrosc. 2015. PMID: 25448973
SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy.
Roshandel D, Sanders EJ, Shakeshaft A, Panjwani N, Lin F, Collingwood A, Hall A, Keenan K, Deneubourg C, Mirabella F, Topp S, Zarubova J, Thomas RH, Talvik I, Syvertsen M, Striano P, Smith AB, Selmer KK, Rubboli G, Orsini A, Ng CC, Møller RS, Lim KS, Hamandi K, Greenberg DA, Gesche J, Gardella E, Fong CY, Beier CP, Andrade DM, Jungbluth H, Richardson MP, Pastore A, Fanto M, Pal DK, Strug LJ; BIOJUME Consortium. Roshandel D, et al. NPJ Genom Med. 2023 Sep 28;8(1):28. doi: 10.1038/s41525-023-00370-z. NPJ Genom Med. 2023. PMID: 37770509 Free PMC article.
Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability.
Thirawatananond P, Brown ME, Sachs LK, Arnoletti JM, Yeh WI, Posgai AL, Shapiro MR, Chen YG, Brusko TM. Thirawatananond P, et al. Diabetes. 2023 Nov 1;72(11):1629-1640. doi: 10.2337/db23-0307. Diabetes. 2023. PMID: 37625150 Free PMC article.
Costimulation serves as a critical checkpoint for T-cell activation, and several genetic variants affecting costimulatory pathways confer risk for autoimmune diseases. ...CD226-deficient pancreatic Tregs had increased expression of the coinhibitory counter-receptor T-cell …
Costimulation serves as a critical checkpoint for T-cell activation, and several genetic variants affecting costimulatory pathways co …
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration.
Jackson JT, Mulazzani E, Nutt SL, Masters SL. Jackson JT, et al. J Biol Chem. 2021 Aug;297(2):100905. doi: 10.1016/j.jbc.2021.100905. Epub 2021 Jun 19. J Biol Chem. 2021. PMID: 34157287 Free PMC article. Review.
Phosphatidylinositol-specific phospholipase Cgamma2 (PLCgamma2) is a critical signaling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif. These re …
Phosphatidylinositol-specific phospholipase Cgamma2 (PLCgamma2) is a critical signaling molecule activated downstream from a variety of cell …
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor.
Kobayashi H, Terkawi MA, Ota M, Hasegawa T, Yamamoto T, Shimizu T, Sato D, Fujita R, Murakami T, Amizuka N, Iwasaki N, Takahata M. Kobayashi H, et al. Bone Res. 2024 Jun 7;12(1):35. doi: 10.1038/s41413-024-00340-w. Bone Res. 2024. PMID: 38849345 Free PMC article.
DNAX-associated protein 12 kD size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif (ITAM)-signaling adaptor that activates costimulatory signals essential for osteoclastogenesis. ...Our data provide genetic and biochemical e …
DNAX-associated protein 12 kD size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif ( …
114 results