Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.
Steinthorsdottir V, Thorleifsson G, Sulem P, Helgason H, Grarup N, Sigurdsson A, Helgadottir HT, Johannsdottir H, Magnusson OT, Gudjonsson SA, Justesen JM, Harder MN, Jørgensen ME, Christensen C, Brandslund I, Sandbæk A, Lauritzen T, Vestergaard H, Linneberg A, Jørgensen T, Hansen T, Daneshpour MS, Fallah MS, Hreidarsson AB, Sigurdsson G, Azizi F, Benediktsson R, Masson G, Helgason A, Kong A, Gudbjartsson DF, Pedersen O, Thorsteinsdottir U, Stefansson K.
Steinthorsdottir V, et al.
Nat Genet. 2014 Mar;46(3):294-8. doi: 10.1038/ng.2882. Epub 2014 Jan 26.
Nat Genet. 2014.
PMID: 24464100
Notably, this variant is also associated with both greater height and higher body mass index (1.17 cm per allele, P = 5.5 10(-12) and 0.56 kg/m(2) per allele, P = 6.5 10(-7), respectively). In addition, two missense variants in PAM, encoding p.Asp563Gly (frequency of 4 …
Notably, this variant is also associated with both greater height and higher body mass index (1.17 cm per allele, P = 5.5 10(-12) and 0.56 …