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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2014 3
2015 2
2016 2
2017 3
2018 7
2019 8
2020 8
2021 6
2022 3
2024 4
2025 1
2026 0

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38 results

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Page 1
NmeCas9 is an intrinsically high-fidelity genome-editing platform.
Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ. Amrani N, et al. Genome Biol. 2018 Dec 5;19(1):214. doi: 10.1186/s13059-018-1591-1. Genome Biol. 2018. PMID: 30518407 Free PMC article.
Homologous recombination deficiency should be tested for in patients with advanced stage high-grade serous ovarian cancer aged 70 years and over.
Pitiyarachchi O, Ansell PJ, Coleman RL, Dinh MH, Holman L, Leath CA 3rd, Werner T, DiSilvestro P, Morgan M, Tew W, Lee C, Cunningham M, Newton M, Edraki B, Lim P, Barlin J, Spirtos NM, Tewari KS, Edelson M, Reid T, Carlson J, Friedlander M. Pitiyarachchi O, et al. Gynecol Oncol. 2024 Aug;187:221-226. doi: 10.1016/j.ygyno.2024.05.021. Epub 2024 May 30. Gynecol Oncol. 2024. PMID: 38821039 Free article. Clinical Trial.
CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
Meijboom KE, Abdallah A, Fordham NP, Nagase H, Rodriguez T, Kraus C, Gendron TF, Krishnan G, Esanov R, Andrade NS, Rybin MJ, Ramic M, Stephens ZD, Edraki A, Blackwood MT, Kahriman A, Henninger N, Kocher JA, Benatar M, Brodsky MH, Petrucelli L, Gao FB, Sontheimer EJ, Brown RH, Zeier Z, Mueller C. Meijboom KE, et al. Nat Commun. 2022 Oct 21;13(1):6286. doi: 10.1038/s41467-022-33332-7. Nat Commun. 2022. PMID: 36271076 Free PMC article.
N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease.
Haghighijoo Z, Akrami S, Saeedi M, Zonouzi A, Iraji A, Larijani B, Fakherzadeh H, Sharifi F, Arzaghi SM, Mahdavi M, Edraki N. Haghighijoo Z, et al. Bioorg Chem. 2020 Oct;103:104146. doi: 10.1016/j.bioorg.2020.104146. Epub 2020 Jul 28. Bioorg Chem. 2020. PMID: 32777579
In addition, compounds 7g and 7h (4-bromo derivative) showed the highest BuChE inhibitory activity with IC(50) of 3.2 and 2.5 M, respectively. Compound 7g also possessed antioxidant activity with an IC(50) value of 10.2 muM and metal chelation potential. ...
In addition, compounds 7g and 7h (4-bromo derivative) showed the highest BuChE inhibitory activity with IC(50) of 3.2 and 2.5 M, res …
Design, synthesis and anti-Alzheimer's activity of novel 1,2,3-triazole-chromenone carboxamide derivatives.
Rastegari A, Nadri H, Mahdavi M, Moradi A, Mirfazli SS, Edraki N, Moghadam FH, Larijani B, Akbarzadeh T, Saeedi M. Rastegari A, et al. Bioorg Chem. 2019 Mar;83:391-401. doi: 10.1016/j.bioorg.2018.10.065. Epub 2018 Oct 30. Bioorg Chem. 2019. PMID: 30412794
Among them, N-(1-benzylpiperidin-4-yl)-7-((1-(3,4-dimethylbenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-oxo-2H-chromene-3-carboxamide (11b) showed the best acetylcholinesterase inhibitory activity (IC(50) = 1.80 M), however, it was inactive toward butyrylcholinesterase. It sho …
Among them, N-(1-benzylpiperidin-4-yl)-7-((1-(3,4-dimethylbenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-oxo-2H-chromene-3-carboxamide (11b) showe …
Design and synthesis of novel coumarin-pyridinium hybrids: In vitro cholinesterase inhibitory activity.
Vafadarnejad F, Mahdavi M, Karimpour-Razkenari E, Edraki N, Sameem B, Khanavi M, Saeedi M, Akbarzadeh T. Vafadarnejad F, et al. Bioorg Chem. 2018 Apr;77:311-319. doi: 10.1016/j.bioorg.2018.01.013. Epub 2018 Jan 31. Bioorg Chem. 2018. PMID: 29421707
Among synthesized compounds, 1-(3-fluorobenzyl)-4-((2-oxo-2H-chromene-3-carboxamido)methyl)pyridinium bromide (7l) was found to be the most active compound toward AChE (IC(50) = 10.14 M), 1-(3-chlorobenzyl)-3-((2-oxo-2H-chromene-3-carboxamido)methyl)pyridinium bromide (7g …
Among synthesized compounds, 1-(3-fluorobenzyl)-4-((2-oxo-2H-chromene-3-carboxamido)methyl)pyridinium bromide (7l) was found to be the most …
5-Oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridine derivatives as promising antiproliferative agents with potential apoptosis-inducing capacity.
Ranjbar S, Khoshneviszadeh M, Tavakkoli M, Miri R, Edraki N, Firuzi O. Ranjbar S, et al. Mol Divers. 2022 Jun;26(3):1481-1500. doi: 10.1007/s11030-021-10281-9. Epub 2021 Oct 20. Mol Divers. 2022. PMID: 34671894
Five best compounds with IC(50) values in the range of 9.5-22.9 M against MOLT-4 cells were selected for cell-cycle analysis, which revealed that derivatives D5, E3, and E5 with 2,3-dichlorophenyl, 3-nitrophenyl, and 2-nitrophenyl substitutions at C(4) position, respectiv …
Five best compounds with IC(50) values in the range of 9.5-22.9 M against MOLT-4 cells were selected for cell-cycle analysis, which …
Evaluation of left ventricular function by tissue Doppler and speckle-derived strain rate echocardiography after percutaneous ductus closure.
Amoogzar H, Shakiba AM, Derakhshan D, Ajami G, Cheriki S, Borzouee M, Edraki MR, Mehdizadegan N. Amoogzar H, et al. Pediatr Cardiol. 2015 Jan;36(1):219-25. doi: 10.1007/s00246-014-0989-0. Epub 2014 Aug 9. Pediatr Cardiol. 2015. PMID: 25107547

Early and late diastolic flow velocities of mitral (E M and A M) reduced considerably in early and late post-closure time (P < 0.05). Both early tissue Doppler early velocity of lateral mitral annulus (E'M) and early to late velocity ratio (E'M/A'

…
Early and late diastolic flow velocities of mitral (E M and A M) reduced considerably in early and late post-closure time (P & …
Permanent longitudinal strain damage of cardiotoxic drugs in childhood cancer: What is the safe level?
Mohammadi H, Hosseini H, Bordbar M, Mehdizadegan N, Amoozgar H, Edraki MR, Naghshzan A, Naderi N, Abedi E, Keshavarz K. Mohammadi H, et al. Ann Pediatr Cardiol. 2024 Jan-Feb;17(1):36-44. doi: 10.4103/apc.apc_146_23. Epub 2024 May 24. Ann Pediatr Cardiol. 2024. PMID: 38933046 Free PMC article.
Among CR patients, those with impaired GLS (n = 43, GLS worse than -21.9) had significantly higher mean age and cumulative anthracycline dose compared to CR patients with normal GLS (age, P = 0.024; anthracycline dosage, P = 0.036). Using an anthracycline cutoff of 223 mg/m …
Among CR patients, those with impaired GLS (n = 43, GLS worse than -21.9) had significantly higher mean age and cumulative anthracycline dos …
38 results