5-Lipoxygenase and cyclooxygenase inhibitory dammarane triterpenoid 1 from Borassus flabellifer seed coat inhibits tumor necrosis factor-α secretion in LPSInduced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 pancreatic cancer cells.
Yarla NS, Azad R, Basha M, Rajack A, Kaladhar DS, Allam BK, Pragada RR, Singh KN, K SK, Pallu R, Parimi U, Bishayee A, Duddukuri GR.
Yarla NS, et al.
Anticancer Agents Med Chem. 2015;15(8):1066-77. doi: 10.2174/1871520615666150202110936.
Anticancer Agents Med Chem. 2015.
PMID: 25642980
Dammarane triterpenoid 1 showed good antiproliferative activity on MIA PaCa-2 pancreatic cancer cell line with IC50 of 12.360.33 M, among other tested cell lines. Apoptosis inducing activity of dammarane triterpenoid 1 was confirmed based on increased sub-G0 phase cell pop …
Dammarane triterpenoid 1 showed good antiproliferative activity on MIA PaCa-2 pancreatic cancer cell line with IC50 of 12.360.33 M, a …