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Page 1
Increasing Antioxidant Activity in Food Waste Extracts by β-Glucosidase.
Karami F, Ghorbani M, Sadeghi Mahoonak A, Pourhossein A, Bagheri A, Khodarahmi R. Karami F, et al. Food Technol Biotechnol. 2022 Dec;60(4):458-468. doi: 10.17113/ftb.60.04.22.7443. Food Technol Biotechnol. 2022. PMID: 36816873 Free PMC article.
The thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) results showed the beta-glucosidase efficacy to hydrolyze quercetin glucosides in onion peel extract, and the quercetin concentration increased from (0.480.04) mg/mL in the untreated extract to …
The thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) results showed the beta-glucosidase efficacy to hydrol …
Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies.
Esmaeili S, Azizian S, Shahmoradi B, Moradi S, Shahlaei M, Khodarahmi R. Esmaeili S, et al. Bioorg Chem. 2019 Jul;88:102972. doi: 10.1016/j.bioorg.2019.102972. Epub 2019 May 6. Bioorg Chem. 2019. PMID: 31078769
DP inhibited the alpha-Glu and alpha-Amy activity in a dose dependent manner with IC(50) values 19.4 0.3 and 30.1 0.4 M, respectively. Further, the K(i) values of DP for alpha-Glu and alpha-Amy were determined as 2.9 0.2 and 3.1 0.4 M in a competitive-mode and mixed …
DP inhibited the alpha-Glu and alpha-Amy activity in a dose dependent manner with IC(50) values 19.4 0.3 and 30.1 0.4 M, respectively …
Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor.
Azimi F, Azizian H, Najafi M, Khodarahmi G, Saghaei L, Hassanzadeh M, Ghasemi JB, Faramarzi MA, Larijani B, Hassanzadeh F, Mahdavi M. Azimi F, et al. Sci Rep. 2021 Oct 21;11(1):20776. doi: 10.1038/s41598-021-99899-1. Sci Rep. 2021. PMID: 34675367 Free PMC article.
Newly identified inhibitors were found to be four to eighteen folds more active with IC(50) values in the range of 40.6 0.2-164.3 1.8 M, as compared to the standard drug acarbose (IC(50) = 750.0 10.0 muM). Limited Structure-activity relationship was established. ...
Newly identified inhibitors were found to be four to eighteen folds more active with IC(50) values in the range of 40.6 0.2-164.3 1.8 M
Novel Aldimine-Type Schiff Bases of 4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1,2,4-triazole-3-thione/thiol: Docking Study, Synthesis, Biological Evaluation, and Anti-Tubulin Activity.
Ameri A, Khodarahmi G, Hassanzadeh F, Forootanfar H, Hakimelahi GH. Ameri A, et al. Arch Pharm (Weinheim). 2016 Aug;349(8):662-81. doi: 10.1002/ardp.201600021. Epub 2016 Jun 19. Arch Pharm (Weinheim). 2016. PMID: 27320785
Evaluation of the cytotoxic effect of the most efficient compounds of the docking steps (H-25) revealed IC50 values of 12.48 1.10, 4.25 0.22, 3.33 0.31, and 9.71 0.75 M against the HT1080, HT29, MCF-7, and A549 cell lines, respectively, compared to doxorubicin (12.69 1.23, …
Evaluation of the cytotoxic effect of the most efficient compounds of the docking steps (H-25) revealed IC50 values of 12.48 1.10, 4.25 0.22 …
TSGA10 Over Expression Decreases Metastasic and Metabolic Activity by Inhibiting HIF-1 in Breast Cancer Cells.
Jahani M, Shahlaei M, Norooznezhad F, Miraghaee SS, Hosseinzadeh L, Moasefi N, Khodarahmi R, Farokhi A, Mahnam A, Mansouri K. Jahani M, et al. Arch Med Res. 2020 Jan;51(1):41-53. doi: 10.1016/j.arcmed.2019.12.002. Epub 2020 Feb 18. Arch Med Res. 2020. PMID: 32086108
RESULTS: Our results showed decrease of cell proliferation and cell cycle arrest in G2/M phase. Reduce expression of GLUT1, lactate production and reactive oxygen species (ROS) below their basal level indicated decreased metabolic activity. ...
RESULTS: Our results showed decrease of cell proliferation and cell cycle arrest in G2/M phase. Reduce expression of GLUT1, lactate p …
New-Generation Low-Field Magnetic Resonance Imaging of Hip Arthroplasty Implants Using Slice Encoding for Metal Artifact Correction: First In Vitro Experience at 0.55 T and Comparison With 1.5 T.
Khodarahmi I, Brinkmann IM, Lin DJ, Bruno M, Johnson PM, Knoll F, Keerthivasan MB, Chandarana H, Fritz J. Khodarahmi I, et al. Invest Radiol. 2022 Aug 1;57(8):517-526. doi: 10.1097/RLI.0000000000000866. Epub 2022 Mar 4. Invest Radiol. 2022. PMID: 35239614 Free PMC article.
Molecular cloning, expression, and functional characterization of 70-kDa heat shock protein, DnaK, from Bacillus halodurans.
Vahdani F, Ghafouri H, Sarikhan S, Khodarahmi R. Vahdani F, et al. Int J Biol Macromol. 2019 Sep 15;137:151-159. doi: 10.1016/j.ijbiomac.2019.06.217. Epub 2019 Jun 28. Int J Biol Macromol. 2019. PMID: 31260773
Also, salt resistance experiments indicated that E. coli + DnaK survival had enhanced by 4.4-fold as compared with control cells in 0.4 M NaCl. The number of E. coli + DnaK colonies was 2.5-fold higher than control colonies in pH 9.5. ...
Also, salt resistance experiments indicated that E. coli + DnaK survival had enhanced by 4.4-fold as compared with control cells in 0.4 M
Synthesis, Characterization, Molecular Modeling, and DNA Interaction Studies of Copper Complex Containing Food Additive Carmoisine Dye.
Shahabadi N, Akbari A, Jamshidbeigi M, Khodarahmi R. Shahabadi N, et al. Nucleosides Nucleotides Nucleic Acids. 2016 Jun 2;35(6):315-33. doi: 10.1080/15257770.2016.1163378. Epub 2016 May 6. Nucleosides Nucleotides Nucleic Acids. 2016. PMID: 27152751
UV-vis results confirmed that the Cu complex interacted with DNA to form a ground-state complex and the observed binding constant (2 10(4) M(-1)) is more in keeping with the groove bindings with DNA. Furthermore, the viscosity measurement result showed that the addition of …
UV-vis results confirmed that the Cu complex interacted with DNA to form a ground-state complex and the observed binding constant (2 10(4) …
Diethylalkylsulfonamido(4-methoxyphenyl)methyl)phosphonate/phosphonic acid derivatives act as acid phosphatase inhibitors: synthesis accompanied by experimental and molecular modeling assessments.
Alimoradi N, Ashrafi-Kooshk MR, Shahlaei M, Maghsoudi S, Adibi H, McGeary RP, Khodarahmi R. Alimoradi N, et al. J Enzyme Inhib Med Chem. 2017 Dec;32(1):20-28. doi: 10.1080/14756366.2016.1230109. Epub 2016 Oct 21. J Enzyme Inhib Med Chem. 2017. PMID: 27766897 Free PMC article.
Hexadecyl derivatives, as most potent compounds (K(i) = 1.1 M), inhibit rkbPAP in the mixed manner, while dodecyl derivatives act as efficient noncompetitive inhibitor. ...
Hexadecyl derivatives, as most potent compounds (K(i) = 1.1 M), inhibit rkbPAP in the mixed manner, while dodecyl derivatives act as …
Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents.
Poorirani S, Sadeghian-Rizi S, Khodarahmi G, Khajouei MR, Hassanzadeh F. Poorirani S, et al. Res Pharm Sci. 2018 Oct;13(5):450-459. doi: 10.4103/1735-5362.236838. Res Pharm Sci. 2018. PMID: 30271447 Free PMC article.
In the first part, 6-(4-amino-3-methylphenoxy)quinoxaline-2,3(1H,4H)-dione was prepared from para-amino -m-crozol in 5 steps. In the next part, 2-alkyl-4H-benzo[d][1,3]oxazin-4-one derivatives were obtained from antranilic acid. ...
In the first part, 6-(4-amino-3-methylphenoxy)quinoxaline-2,3(1H,4H)-dione was prepared from para-amino -m-crozol in 5 steps. In the …
18 results