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Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.
Mueller SH, Lai AG, Valkovskaya M, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Abu-Ful Z, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baert T, Freeman LEB, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Brenner H, Brucker SY, Buys SS, Castelao JE, Chan TL, Chang-Claude J, Chanock SJ, Choi JY, Chung WK; NBCS Collaborators; Colonna SV; CTS Consortium; Cornelissen S, Couch FJ, Czene K, Daly MB, Devilee P, Dörk T, Dossus L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Engel C, Evans DG, Fasching PA, Fletcher O, Flyger H, Gago-Dominguez M, Gao YT, García-Closas M, García-Sáenz JA, Genkinger J, Gentry-Maharaj A, Grassmann F, Guénel P, Gündert M, Haeberle L, Hahnen E, Haiman CA, Håkansson N, Hall P, Harkness EF, Harrington PA, Hartikainen JM, Hartman M, Hein A, Ho WK, Hooning MJ, Hoppe R, Hopper JL, Houlston RS, Howell A, Hunter DJ, Huo D; ABCTB Investigators; Ito H, Iwasaki M, Jakubowska A, Janni W, John EM, Jones ME, Jung A, Kaaks R, Kang D, Khusnutdinova EK, Kim SW, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kubelka-Sabit K, Kurian AW, Kwong A, Lacey JV, Lambrechts D, Le March… See abstract for full author list ➔ Mueller SH, et al. Genome Med. 2023 Jan 26;15(1):7. doi: 10.1186/s13073-022-01152-5. Genome Med. 2023. PMID: 36703164 Free PMC article.
Of those, two genes, FMNL3 (P = 6.11 10(-6)) and AC058822.1 (P = 1.47 10(-4)), represent new associations. High FMNL3 expression has previously been linked to poor prognosis in several other cancers. Meta-analysis of samples with diverse ancestry discovered further associa …
Of those, two genes, FMNL3 (P = 6.11 10(-6)) and AC058822.1 (P = 1.47 10(-4)), represent new associations. High FMNL3 expression has previou …
coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit.
Podda M, Pacella D, Pellino G, Coccolini F, Giordano A, Di Saverio S, Pata F, Ielpo B, Virdis F, Damaskos D, De Simone B, Agresta F, Sartelli M, Leppaniemi A, Riboni C, Agnoletti V, Mole D, Kluger Y, Catena F, Pisanu A; MANCTRA-1 Collaborative Group; Principal Investigator; Steering Committee; MANCTRA-1 Coordinating Group; Local Collaborators; Argentina; Australia; Bahrain; Brazil; Bulgaria; China; Colombia; Czech Republic; Egypt; France; Georgia; Greece; Guatemala; India; Italy; Jordan; Malaysia; Mexico; Nigeria; Pakistan; Paraguay; Peru; Philippines; Poland; Portugal; Qatar; Romania; Russia; Serbia; Slovak Republic; South Africa; Spain; Sudan; Switzerland; Syria; Tunisia; Turkey; United Kingdom; Uruguay; Yemen. Podda M, et al. Pancreatology. 2022 Nov;22(7):902-916. doi: 10.1016/j.pan.2022.07.007. Epub 2022 Jul 16. Pancreatology. 2022. PMID: 35963665

The most commonly discordant gaps between daily clinical practice and recommendations included the optimal timing for the index CT scan (6.1%, chi(2) 6.71, P = 0.081), use of prophylactic antibiotics (44.2%, chi(2) 221.05, P < 0.00001), early enteral feeding (33.2%, chi(2) 11.

The most commonly discordant gaps between daily clinical practice and recommendations included the optimal timing for the index CT scan (6.1 …
Feasibility of a tailored ERAS programme in octogenarian patients undergoing minimally invasive surgery for colorectal cancer.
Depalma N, Cassini D, Grieco M, Barbieri V, Altamura A, Manoochehri F, Viola M, Baldazzi G. Depalma N, et al. Aging Clin Exp Res. 2020 Feb;32(2):265-273. doi: 10.1007/s40520-019-01195-6. Epub 2019 Apr 13. Aging Clin Exp Res. 2020. PMID: 30982218
Univariate and multivariate analyses were performed to assess possible risk factors for poor clinical outcomes. RESULTS: The postoperative minor morbidity rate (Clavien-Dindo 1 and 2) was 25.9%. ...A univariate analysis showed that possible risk factors for severe medical …
Univariate and multivariate analyses were performed to assess possible risk factors for poor clinical outcomes. RESULTS: The postoper …