Synthesis and tyrosinase inhibitory activities of novel isopropylquinazolinones.
Hashemi A, Noori M, Dastyafteh N, Sadat-Ebrahimi SE, Fazelzadeh Haghighi N, Mehrpour K, Sattarinezhad E, Jalali Zafrei F, Irajie C, Daneshmehr MA, Heydari M, Larijani B, Iraji A, Mahdavi M.
Hashemi A, et al.
BMC Chem. 2023 Jun 23;17(1):65. doi: 10.1186/s13065-023-00978-3.
BMC Chem. 2023.
PMID: 37353836
Free PMC article.
All derivatives were evaluated as possible tyrosinase inhibitors and compound 9q bearing 4-fluorobenzyl moieties at the R position exhibited the best potencies with an IC(50) value of 34.67 3.68 M. The kinetic evaluations of 9q as the most potent derivatives recorded mi …
All derivatives were evaluated as possible tyrosinase inhibitors and compound 9q bearing 4-fluorobenzyl moieties at the R position exhibited …