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277 results

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Page 1
Did you mean m mri (40,864 results)?
Suxiao Jiuxin Pill alleviates myocardial ischemia/reperfusion-induced autophagy via miR-193a-3p/ALKBH5 pathway.
Wang D, Wang D, Jin Q, Wang X. Wang D, et al. Phytomedicine. 2024 Mar;125:155359. doi: 10.1016/j.phymed.2024.155359. Epub 2024 Jan 24. Phytomedicine. 2024. PMID: 38301300 Free article.
Methylation of N6-methyladenosine (m(6)A), which is the most common post-transcriptional modifications occurring within mammalian mRNA, is believed to be involved in MIRI by modulating autophagy. ...CONCLUSION: We demonstrated that SJP mitigates autophagy in MIRI …
Methylation of N6-methyladenosine (m(6)A), which is the most common post-transcriptional modifications occurring within mammalian mRN …
WTAP-mediated m(6)A modification of lncRNA Snhg1 improves myocardial ischemia-reperfusion injury via miR-361-5p/OPA1-dependent mitochondrial fusion.
Liu L, Wu J, Lu C, Ma Y, Wang J, Xu J, Yang X, Zhang X, Wang H, Xu J, Zhang J. Liu L, et al. J Transl Med. 2024 May 25;22(1):499. doi: 10.1186/s12967-024-05330-4. J Transl Med. 2024. PMID: 38796415 Free PMC article.
N6-methyladenosine (m(6)A) is the frequent RNA modification and plays a critical role in MIRI. However, it is unclear whether lncRNA Snhg1 regulates MIRI progression and whether the lncRNA Snhg1 was modified by m(6)A methylation. ...CONCLUSION: WTAP-me …
N6-methyladenosine (m(6)A) is the frequent RNA modification and plays a critical role in MIRI. However, it is unclear whether …
Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation.
Zhang H, Liu L, Shen C, Jiang X, Liu J, Chen J, Xu S, Mo Y. Zhang H, et al. Research (Wash D C). 2025 May 30;8:0705. doi: 10.34133/research.0705. eCollection 2025. Research (Wash D C). 2025. PMID: 40452820 Free PMC article.
Deoxyribonuclease I, NET inhibitor, was injected into MIRI rats to evaluate the in vivo effects of NET modulation on MIRI severity. Results: MIRI was often accompanied by cardiac microvascular endothelial cell (CMEC) injury and inflammation. ...Elevated NET l …
Deoxyribonuclease I, NET inhibitor, was injected into MIRI rats to evaluate the in vivo effects of NET modulation on MIRI seve …
Homotransplantation of Engineered Macrophages with Surface-Modified Nanomedicines for Mitigating Myocardial Ischemia-Reperfusion Injury.
Cheng J, Gao R, Lyu Y, Xiong Z, Yang K, Zhao X, Huang X, Xu L, Guo L, Wang W, Li Y, Ding W, Guo P, Ji Z, Li W, Han X, Zhang J, Suo S, Zhao H, Jiang L, Zhang Q, Li B, Wu L, Zhou Y. Cheng J, et al. ACS Nano. 2025 Jul 15;19(27):25069-25087. doi: 10.1021/acsnano.5c05068. Epub 2025 Jun 27. ACS Nano. 2025. PMID: 40579350
Here, we developed a syngenic reparative macrophage system for the selective delivery of nanoscale drugs by modifying liposomes loaded with nano-Pt/Se and c176 onto the surface of M2 macrophages (PS-c@M). In MIRI mice, transplanted PS-c@M was actively recruit …
Here, we developed a syngenic reparative macrophage system for the selective delivery of nanoscale drugs by modifying liposomes loaded with …
Cardiosplenic axis-targeted immunomodulatory liposome for myocardial ischemia-reperfusion injury treatment.
Dong J, Li Z, Fu C, Yang D, Yang H, Lin L, Liang XJ, Chen Z, Chen L, Guo W. Dong J, et al. J Control Release. 2025 Jul 10;383:113799. doi: 10.1016/j.jconrel.2025.113799. Epub 2025 May 3. J Control Release. 2025. PMID: 40324533
Monocyte/macrophage (Mo/M) infiltration is critical in myocardial ischemia-reperfusion injury (MIRI). However, the complex composition of the myocardium severely hinders drug accumulation and makes it challenging to modulate the Mo/M immune response at the …
Monocyte/macrophage (Mo/M) infiltration is critical in myocardial ischemia-reperfusion injury (MIRI). However, the complex com …
Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury.
Li Y, Chen Y, Yu P, Zhang D, Tang X, Zhu Z, Xiao F, Deng W, Liu Y, Tan Z, Zhang J, Yu S. Li Y, et al. Mol Med Rep. 2024 Dec;30(6):220. doi: 10.3892/mmr.2024.13345. Epub 2024 Oct 4. Mol Med Rep. 2024. PMID: 39364741 Free PMC article.
These experiments revealed that MTH could effectively reduce myocardial infarct size, improve hemodynamic performance following MIRI and suppress myocardial apoptosis, thereby contributing to the recovery from H/R injury. ...Taken together, the results of the present study …
These experiments revealed that MTH could effectively reduce myocardial infarct size, improve hemodynamic performance following MIRI …
Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m(6)A modification of Trio mRNA.
Li J, Chen J, Zhao M, Li Z, Liu N, Fang H, Fang M, Zhu P, Lei L, Chen C. Li J, et al. Ann Transl Med. 2022 Apr;10(7):417. doi: 10.21037/atm-22-1289. Ann Transl Med. 2022. PMID: 35530959 Free PMC article.
However, the mechanisms of m(6)A modification in myocardial ischemia/reperfusion injury (MIRI) remain unclear. ...Finally, the mRNA levels of the promising targeted gene were examined by RT-qPCR and its m(6)A modification levels were examined by MeRIP-qPCR. R …
However, the mechanisms of m(6)A modification in myocardial ischemia/reperfusion injury (MIRI) remain unclear. ...Finally, the …
277 results