6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cells.
Daneshmandi S, Yan Q, Gomez EC, Choi JE, Katsuta E, Gharib E, Singh PK, Higashi RM, Lane AN, Fan TW, Wang J, Repasky EA, McCarthy PL, Mohammadpour H.
Daneshmandi S, et al.
Nat Commun. 2026 Jan 14;17(1):229. doi: 10.1038/s41467-025-68102-8.
Nat Commun. 2026.
PMID: 41535266
Free PMC article.
Here, we identify 6-phosphogluconate dehydrogenase (6PGD), a rate-limiting enzyme in the pentose phosphate pathway (PPP), as an important regulator of monocytic-myeloid derived suppressor cell (M-MDSC) function. Our findings reveal that tumor M-MDSCs upregulate 6PGD …
Here, we identify 6-phosphogluconate dehydrogenase (6PGD), a rate-limiting enzyme in the pentose phosphate pathway (PPP), as an important re …