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14,051 results

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Page 1
Showing results for m pan
Search for M Panj instead (2 results)
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.
Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P. Liu C, et al. Adv Sci (Weinh). 2024 Jun;11(23):e2401061. doi: 10.1002/advs.202401061. Epub 2024 Apr 3. Adv Sci (Weinh). 2024. PMID: 38569519 Free PMC article.
Comprehensive single-cell analysis as well as in vivo and in vitro experiments are applied to explore the potential mechanisms of the APOE(+) macrophage in affecting ICI response. The M.Sig model shows clear advantages in predicting the efficacy and prognosis of ICI therap …
Comprehensive single-cell analysis as well as in vivo and in vitro experiments are applied to explore the potential mechanisms of the APOE(+ …
Interplay of RNA m(6)A Modification-Related Geneset in Pan-Cancer.
Zhang B, Hao Y, Liu H, Wu J, Lu L, Wang X, Bajpai AK, Yang X. Zhang B, et al. Biomedicines. 2024 Sep 27;12(10):2211. doi: 10.3390/biomedicines12102211. Biomedicines. 2024. PMID: 39457524 Free PMC article.
Significant correlations of the regulators with clinicopathological parameters, such as age, gender, tumor stage, and grade are identified in pan-cancer. The m(6)A regulators' expression is found to have significant positive correlations with the miRNAs in pan
Significant correlations of the regulators with clinicopathological parameters, such as age, gender, tumor stage, and grade are identified i …
M&M: an RNA-seq based pan-cancer classifier for paediatric tumours.
Wallis FSA, Baker-Hernandez JL, van Tuil M, van Hamersveld C, Koudijs MJ, Verwiel ETP, Janse A, Hiemcke-Jiwa LS, de Krijger RR, Kranendonk MEG, Vermeulen MA, Wesseling P, Flucke UE, de Haas V, Luesink M, Hoving EW, Vormoor JH, van Noesel MM, Hehir-Kwa JY, Tops BBJ, Kemmeren P, Kester LA. Wallis FSA, et al. EBioMedicine. 2025 Jan;111:105506. doi: 10.1016/j.ebiom.2024.105506. Epub 2024 Dec 21. EBioMedicine. 2025. PMID: 39709770 Free PMC article.
However, advances in genome wide profiling techniques such as RNA sequencing now allow the development of molecular classification tools. METHODS: Here, we present M&M, a pan-paediatric cancer ensemble-based machine learning algorithm tailored towards inc …
However, advances in genome wide profiling techniques such as RNA sequencing now allow the development of molecular classification tools. ME …
Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors.
Lee JK, Sivakumar S, Schrock AB, Madison R, Fabrizio D, Gjoerup O, Ross JS, Frampton GM, Napalkov P, Montesion M, Schutzman JL, Ye X, Hegde PS, Nagasaka M, Oxnard GR, Sokol ES, Ou SI, Shi Z. Lee JK, et al. NPJ Precis Oncol. 2022 Dec 9;6(1):91. doi: 10.1038/s41698-022-00334-z. NPJ Precis Oncol. 2022. PMID: 36494601 Free PMC article.
Recent clinical development of KRAS inhibitors has heightened interest in the genomic landscape of KRAS-altered cancers. We performed a pan-cancer analysis of KRAS-altered samples from 426,706 adult patients with solid or hematologic malignancies using comprehensive genomi …
Recent clinical development of KRAS inhibitors has heightened interest in the genomic landscape of KRAS-altered cancers. We performed a p
Literature Commentary.
[No authors listed] [No authors listed] J Neuroophthalmol. 2023 Mar 1;43(1):e26-e36. doi: 10.1097/WNO.0000000000001813. Epub 2023 Jan 18. J Neuroophthalmol. 2023. PMID: 40418693
Ophthalmol Ther. 2022. doi: 10.1007/s40123-022-00611-x.Noll C, Hiltensperger M, Aly L, Wicklein R, Afzali AM, Mardin C, Gasperi C, Berthele A, Hemmer B, Korn T, Knier B. ...Front Immunol. 2022;13:997043.Mitchell JL, Buckham R, Lyons H, Walker JK, Yiangou A, Sassani M
Ophthalmol Ther. 2022. doi: 10.1007/s40123-022-00611-x.Noll C, Hiltensperger M, Aly L, Wicklein R, Afzali AM, Mardin C, Gasperi C, Be …
An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting M(pro).
Zhang J, Zhao L, Bai Y, Li S, Zhang M, Wei B, Wang X, Xue Y, Li L, Ma G, Tang Y, Wang X. Zhang J, et al. Bioorg Med Chem Lett. 2024 May 1;103:129706. doi: 10.1016/j.bmcl.2024.129706. Epub 2024 Mar 19. Bioorg Med Chem Lett. 2024. PMID: 38508325
Here, we developed and refined an enzymatic technique to identify putative M(pro) inhibitors from 189 marine chemicals and 46 terrestrial natural products. The IC(50) values of Polycarpine (1a), a marine natural substance we studied and synthesized, are 30.0 2.5 nM for S …
Here, we developed and refined an enzymatic technique to identify putative M(pro) inhibitors from 189 marine chemicals and 46 terrest …
The m(6)A landscape of polyadenylated nuclear (PAN) RNA and its related methylome in the context of KSHV replication.
Martin SE, Gan H, Toomer G, Sridhar N, Sztuba-Solinska J. Martin SE, et al. RNA. 2021 Sep;27(9):1102-1125. doi: 10.1261/rna.078777.121. Epub 2021 Jun 29. RNA. 2021. Retraction in: RNA. 2022 Feb;28(2):274. doi: 10.1261/rna.079042.121. PMID: 34187903 Free PMC article. Retracted.
Here, we combined antibody-independent next-generation mapping with direct RNA sequencing to address the epitranscriptomic status of PAN RNA in KSHV infected cells. We showed that PAN m(6)A status is dynamic, reaching the highest number of modifications at th …
Here, we combined antibody-independent next-generation mapping with direct RNA sequencing to address the epitranscriptomic status of PAN
Pan-Cancer Analysis Links Altered RNA m(7)G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival.
Su A, Song R, Wong JJ. Su A, et al. Cancer Rep (Hoboken). 2024 Jul;7(7):e2138. doi: 10.1002/cnr2.2138. Cancer Rep (Hoboken). 2024. PMID: 39041608 Free PMC article.
BACKGROUND: N7-methylguanosine (m(7)G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m(7)G modifications caused by aberrant expression of m(7)G writers contribute to cancer progression and result in worse patient survival …
BACKGROUND: N7-methylguanosine (m(7)G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m(7 …
Rongrong Pan.
[No authors listed] [No authors listed] Angew Chem Int Ed Engl. 2023 Sep 25;62(39):e202309992. doi: 10.1002/anie.202309992. Epub 2023 Aug 6. Angew Chem Int Ed Engl. 2023. PMID: 37545112
"A turning point in my career was the development of nanokits for the analysis of small molecules and protein activity in single cells I'm always in a good mood when I have a hearty meal and chat with my family after a busy day." Find out more about Rongrong Pan i …
"A turning point in my career was the development of nanokits for the analysis of small molecules and protein activity in single cells I' …
Pan-cancer analysis of m(5)C regulator genes reveals consistent epigenetic landscape changes in multiple cancers.
He Y, Yu X, Zhang M, Guo W. He Y, et al. World J Surg Oncol. 2021 Jul 29;19(1):224. doi: 10.1186/s12957-021-02342-y. World J Surg Oncol. 2021. PMID: 34325709 Free PMC article.
BACKGROUND: 5-Methylcytosine (m(5)C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in developing human cancers are poorly understood, including the effects of mutant m(5)C regulators and the outcomes of modified nucleobases i …
BACKGROUND: 5-Methylcytosine (m(5)C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in develo …
14,051 results
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