Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry.
Bock F, Dong X, Li S, Viquez OM, Sha E, Tantengco M, Hennen EM, Plosa E, Ramezani A, Brown KL, Whang YM, Terker AS, Arroyo JP, Harrison DG, Fogo A, Brakebusch CH, Pozzi A, Zent R.
Bock F, et al.
Sci Adv. 2024 Feb 9;10(6):eadi7840. doi: 10.1126/sciadv.adi7840. Epub 2024 Feb 7.
Sci Adv. 2024.
PMID: 38324689
Free PMC article.
Mechanistically, Rac1 restricted excessive actomyosin activity that stabilized the negative mitotic entry kinase Wee1. This mechanism ensured mechanical G(2)-M checkpoint stability and prevented premature mitotic entry. The repair defects following injury could be rescued …
Mechanistically, Rac1 restricted excessive actomyosin activity that stabilized the negative mitotic entry kinase Wee1. This mechanism ensure …