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185 results

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Page 1
Did you mean m tall (1,456 results)?
A Tale of Two Proteases: M(Pro) and TMPRSS2 as Targets for COVID-19 Therapies.
Farkaš B, Minneci M, Misevicius M, Rozas I. Farkaš B, et al. Pharmaceuticals (Basel). 2023 Jun 2;16(6):834. doi: 10.3390/ph16060834. Pharmaceuticals (Basel). 2023. PMID: 37375781 Free PMC article. Review.
Then, this review discusses some of the most recently reported inhibitors first for the viral M(Pro) and next for the host TMPRSS2 explaining the mechanism of action of each protease. Afterward, some computational approaches to design novel M(Pro) and TMPRSS2 inhibi …
Then, this review discusses some of the most recently reported inhibitors first for the viral M(Pro) and next for the host TMPRSS2 ex …
The IRAK-M death domain: a tale of three surfaces.
Gürkan B, Poelman H, Pereverzeva L, Kruijswijk D, de Vos AF, Groenen AG, Nollet EE, Wichapong K, Lutgens E, van der Poll T, Du J, Wiersinga WJ, Nicolaes GAF, van 't Veer C. Gürkan B, et al. Front Mol Biosci. 2024 Jan 10;10:1265455. doi: 10.3389/fmolb.2023.1265455. eCollection 2023. Front Mol Biosci. 2024. PMID: 38268724 Free PMC article.
The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-kappaB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 depen …
The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signa …
Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases.
Cho SI, Lee S, Mok YG, Lim K, Lee J, Lee JM, Chung E, Kim JS. Cho SI, et al. Cell. 2022 May 12;185(10):1764-1776.e12. doi: 10.1016/j.cell.2022.03.039. Epub 2022 Apr 25. Cell. 2022. PMID: 35472302 Free article.
Here, we present transcription-activator-like effector (TALE)-linked deaminases (TALEDs), composed of custom-designed TALE DNA-binding arrays, a catalytically impaired, full-length DddA variant or split DddA originated from Burkholderia cenocepacia, and an engineere …
Here, we present transcription-activator-like effector (TALE)-linked deaminases (TALEDs), composed of custom-designed TALE DNA …
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.
Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR. Zuris JA, et al. Nat Biotechnol. 2015 Jan;33(1):73-80. doi: 10.1038/nbt.3081. Epub 2014 Oct 30. Nat Biotechnol. 2015. PMID: 25357182 Free PMC article.
This approach mediates the potent delivery of nM concentrations of Cre recombinase, TALE- and Cas9-based transcription activators, and Cas9:sgRNA nuclease complexes into cultured human cells in media containing 10% serum. ...
This approach mediates the potent delivery of nM concentrations of Cre recombinase, TALE- and Cas9-based transcription activators, an …
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group.
El Bairi K, Haynes HR, Blackley E, Fineberg S, Shear J, Turner S, de Freitas JR, Sur D, Amendola LC, Gharib M, Kallala A, Arun I, Azmoudeh-Ardalan F, Fujimoto L, Sua LF, Liu SW, Lien HC, Kirtani P, Balancin M, El Attar H, Guleria P, Yang W, Shash E, Chen IC, Bautista V, Do Prado Moura JF, Rapoport BL, Castaneda C, Spengler E, Acosta-Haab G, Frahm I, Sanchez J, Castillo M, Bouchmaa N, Md Zin RR, Shui R, Onyuma T, Yang W, Husain Z, Willard-Gallo K, Coosemans A, Perez EA, Provenzano E, Ericsson PG, Richardet E, Mehrotra R, Sarancone S, Ehinger A, Rimm DL, Bartlett JMS, Viale G, Denkert C, Hida AI, Sotiriou C, Loibl S, Hewitt SM, Badve S, Symmans WF, Kim RS, Pruneri G, Goel S, Francis PA, Inurrigarro G, Yamaguchi R, Garcia-Rivello H, Horlings H, Afqir S, Salgado R, Adams S, Kok M, Dieci MV, Michiels S, Demaria S, Loi S; International Immuno-Oncology Biomarker Working Group. El Bairi K, et al. NPJ Breast Cancer. 2021 Dec 1;7(1):150. doi: 10.1038/s41523-021-00346-1. NPJ Breast Cancer. 2021. PMID: 34853355 Free PMC article. Review.
A Tale of Two Falls.
Jackson V, Satake A. Jackson V, et al. 2024 Oct 30. In: WebM&M: Case Studies [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2019 Oct 30–. 2024 Oct 30. In: WebM&M: Case Studies [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2019 Oct 30–. PMID: 40591760 Free Books & Documents. Review. No abstract available.
The Degenerate Tale of Ascidian Tails.
Fodor ACA, Powers MM, Andrykovich K, Liu J, Lowe EK, Brown CT, Di Gregorio A, Stolfi A, Swalla BJ. Fodor ACA, et al. Integr Comp Biol. 2021 Sep 8;61(2):358-369. doi: 10.1093/icb/icab022. Integr Comp Biol. 2021. PMID: 33881514 Free PMC article. Review.
Yet surprisingly, we find that the notochord gene regulatory network is mostly intact in the tailless M. occulta, although the notochord does not converge and extend and remains as an aggregate of cells we call the "notoball." ...
Yet surprisingly, we find that the notochord gene regulatory network is mostly intact in the tailless M. occulta, although the notoch …
185 results