Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.
Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, Hancock DC, Tavassoli A, Downward J.
Ismail M, et al.
Sci Rep. 2023 Feb 2;13(1):1889. doi: 10.1038/s41598-023-28756-0.
Sci Rep. 2023.
PMID: 36732563
Free PMC article.
The primary cyclic peptide hit from the screen initially showed a weak affinity for the p110alpha-RBD (K(d) about 360 M). However, two rounds of amino acid substitution led to cyclo-CRVLIR, with an improved affinity for p110alpha-RBD in the low M (K(d) 3 M). …
The primary cyclic peptide hit from the screen initially showed a weak affinity for the p110alpha-RBD (K(d) about 360 M). However, tw …