SARS-CoV-2 M(pro) responds to oxidation by forming disulfide and NOS/SONOS bonds.
Reinke PYA, Schubert R, Oberthür D, Galchenkova M, Rahmani Mashhour A, Günther S, Chretien A, Round A, Seychell BC, Norton-Baker B, Kim C, Schmidt C, Koua FHM, Tolstikova A, Ewert W, Peña Murillo GE, Mills G, Kirkwood H, Brognaro H, Han H, Koliyadu J, Schulz J, Bielecki J, Lieske J, Maracke J, Knoska J, Lorenzen K, Brings L, Sikorski M, Kloos M, Vakili M, Vagovic P, Middendorf P, de Wijn R, Bean R, Letrun R, Han S, Falke S, Geng T, Sato T, Srinivasan V, Kim Y, Yefanov OM, Gelisio L, Beck T, Doré AS, Mancuso AP, Betzel C, Bajt S, Redecke L, Chapman HN, Meents A, Turk D, Hinrichs W, Lane TJ.
Reinke PYA, et al.
Nat Commun. 2024 May 7;15(1):3827. doi: 10.1038/s41467-024-48109-3.
Nat Commun. 2024.
PMID: 38714735
Free PMC article.
The main protease (M(pro)) of SARS-CoV-2 is critical for viral function and a key drug target. M(pro) is only active when reduced; turnover ceases upon oxidation but is restored by re-reduction. ...Here, we report a crystal structure of oxidized M(pro) showin …
The main protease (M(pro)) of SARS-CoV-2 is critical for viral function and a key drug target. M(pro) is only active when redu …
