2-{N-[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ1/2 Receptors.
Deuther-Conrad W, Schepmann D, Iriepa I, López-Muñoz F, Chioua M, Wünsch B, Samadi A, Marco-Contelles J.
Deuther-Conrad W, et al.
Int J Mol Sci. 2025 Jan 31;26(3):1266. doi: 10.3390/ijms26031266.
Int J Mol Sci. 2025.
PMID: 39941036
Free PMC article.
In the search for new small molecule drugs against neuropathic pain, we identified 2-{[2-(1-benzylpiperidin-4-yl)ethyl]amino}-6-[methyl(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitrile (5) as a polyfunctionalized small pyridine with potent dual-target activities against acetylcho …
In the search for new small molecule drugs against neuropathic pain, we identified 2-{[2-(1-benzylpiperidin-4-yl)ethyl]amino}-6-[methyl(prop …