Highly functionalized 2-amino-4H-pyrans as potent cholinesterase inhibitors.
Kumar RS, Almansour AI, Arumugam N, Al-Thamili DM, Basiri A, Kotresha D, Manohar TS, Venketesh S, Asad M, Asiri AM.
Kumar RS, et al.
Bioorg Chem. 2018 Dec;81:134-143. doi: 10.1016/j.bioorg.2018.08.009. Epub 2018 Aug 12.
Bioorg Chem. 2018.
PMID: 30121001
The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC(50) of 1.98 0.09 M against acetylcholinesterase (AChE) and 10.62 0.21 M against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptor …
The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC(50) of 1.98 0.09 M against a …