Pharmacological Inhibition of MDM2 Induces Apoptosis in p53-Mutated Triple-Negative Breast Cancer.
On JL, Ghaderi S, Rittmann C, Hoffmann G, Gier F, Woloschin V, Tu JW, Bhatia S, Kulik A, Niederacher D, Neubauer H, Kurz T, Fehm T, Esser K.
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Int J Mol Sci. 2025 Jan 26;26(3):1078. doi: 10.3390/ijms26031078.
Int J Mol Sci. 2025.
PMID: 39940844
Free PMC article.
When we analyzed anti-tumor activity in the TNBC cell lines MDA-MB-231, MDA-MB-436, and MDA-MB-468, cellular viability was efficiently reduced, with half maximal inhibitory concentration (IC(50)) values ranging between 2.00 and 7.62 M being up to 11-fold lower compared to …
When we analyzed anti-tumor activity in the TNBC cell lines MDA-MB-231, MDA-MB-436, and MDA-MB-468, cellular viability was efficiently reduc …