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Meta-analyses identify DNA methylation associated with kidney function and damage.
Schlosser P, Tin A, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Weihs A, Yu Z, Hoppmann A, Grundner-Culemann F, Min JL, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Breteler MMB, Carmeli C, Chaker L, Chambers JC, Cole SA, Coresh J, Corre T, Correa A, Cox SR, de Klein N, Delgado GE, Domingo-Relloso A, Eckardt KU, Ekici AB, Endlich K, Evans KL, Floyd JS, Fornage M, Franke L, Fraszczyk E, Gao X, Gào X, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Jarvelin MR, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kramer H, Kronenberg F, Kühnel B, Lehtimäki T, Lind L, Liu D, Liu Y, Lloyd-Jones DM, Lohman K, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Navas-Acien A, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Rosas SE, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, Tellez-Plaza M, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Verweij N, Walker RM, Wielscher M, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y… See abstract for full author list ➔ Schlosser P, et al. Nat Commun. 2021 Dec 9;12(1):7174. doi: 10.1038/s41467-021-27234-3. Nat Commun. 2021. PMID: 34887417 Free PMC article.
DNA Methylation Signatures of Systemic Inflammation Are Associated With Brain Volume, Cognitive Trajectories, and Long-Term Dementia Risk.
Drouin SM, Kuo P, Blew C, Duggan MR, Chen D, Smith HM, Chen J, Giorgio K, Gomez G, Moore AZ, Erus G, Davatzikos C, Bressler J, Simino J, Li Y, Gottesman RF, Marioni RE, Sedaghat S, Ferrucci L, Resnick SM, Walker KA. Drouin SM, et al. Aging Cell. 2025 Dec;24(12):e70281. doi: 10.1111/acel.70281. Epub 2025 Nov 22. Aging Cell. 2025. PMID: 41274863 Free PMC article.
Association of Body Mass Index in Late Life, and Change from Midlife to Late Life, With Incident Dementia in the ARIC Study Participants.
Cannon EJ, Windham BG, Griswold M, Palta P, Knopman DS, Sedaghat S, Lutsey PL. Cannon EJ, et al. Neurology. 2025 May 13;104(9):e213534. doi: 10.1212/WNL.0000000000213534. Epub 2025 Apr 11. Neurology. 2025. PMID: 40215425
Next, we used a cross-classification of visit 5 BMI categories with visit 4-visit 5 BMI change (decrease [loss of 2 kg/m(2)], increase [gain of 2 kg/m(2)], or stable [loss or gain of <2 kg/m(2)]) occurring during the 15 years before baseline. ...
Next, we used a cross-classification of visit 5 BMI categories with visit 4-visit 5 BMI change (decrease [loss of 2 kg/m(2)], increa …
Kidney function, bone-mineral metabolism markers, and calcification of coronary arteries, aorta, and cardiac valves in older adults.
Mok Y, Wang F, Ballew SH, Menez S, Butler KR, Wagenknecht L, Sedaghat S, Lutsey PL, Coresh J, Blaha MJ, Matsushita K. Mok Y, et al. Atherosclerosis. 2023 Mar;368:35-43. doi: 10.1016/j.atherosclerosis.2023.01.007. Epub 2023 Jan 13. Atherosclerosis. 2023. PMID: 36754659 Free PMC article.
Among BMM markers, only higher phosphorus levels, even within the normal range, showed robust associations with high CAC (only when modeled continuously) and ECC, independently of kidney function (e.g., odds ratio 1.94 [95%CI 1.38-2.73] for high aortic valve calcification, …
Among BMM markers, only higher phosphorus levels, even within the normal range, showed robust associations with high CAC (only when modeled …
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
Tin A, Schlosser P, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Yu Z, Weihs A, Hoppmann A, Grundner-Culemann F, Min JL, Kuhns VLH, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Bressler J, Breteler MMB, Carmeli C, Chaker L, Coresh J, Corre T, Correa A, Cox SR, Delgado GE, Eckardt KU, Ekici AB, Endlich K, Floyd JS, Fraszczyk E, Gao X, Gào X, Gelber AC, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kronenberg F, Kühnel B, Ladd-Acosta C, Lehtimäki T, Lind L, Liu D, Lloyd-Jones DM, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Völker U, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y; Estonian Biobank Research Team; Genetics of DNA Methylation Consortium; Loh M, Snieder H, Waldenberger M, Levy D, Akilesh S, Woodward OM, S… See abstract for full author list ➔ Tin A, et al. Nat Commun. 2021 Dec 9;12(1):7173. doi: 10.1038/s41467-021-27198-4. Nat Commun. 2021. PMID: 34887389 Free PMC article.
Ecological Niche Modeling of main reservoir hosts of zoonotic cutaneous leishmaniasis in Iran.
Gholamrezaei M, Mohebali M, Hanafi-Bojd AA, Sedaghat MM, Shirzadi MR. Gholamrezaei M, et al. Acta Trop. 2016 Aug;160:44-52. doi: 10.1016/j.actatropica.2016.04.014. Epub 2016 May 2. Acta Trop. 2016. PMID: 27150212
The areas under curve obtained were 0.961, 0.927, 0.922, 0.997 and 0.899, instead of 1, for training test in R. opimus, M. libycus, T. indica, M. hurrianae and N. indica, respectively. The environmental variable with the highest gain when used in isolation was slope …
The areas under curve obtained were 0.961, 0.927, 0.922, 0.997 and 0.899, instead of 1, for training test in R. opimus, M. libycus, T …