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Evaluating the Impact of the Tyr158 pKa on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis.
Davoodi S, Daryaee F, Iuliano JN, Tolentino Collado J, He Y, Pollard AC, Gil AA, Aramini JM, Tonge PJ. Davoodi S, et al. Biochemistry. 2023 Jun 20;62(12):1943-1952. doi: 10.1021/acs.biochem.2c00606. Epub 2023 Jun 4. Biochemistry. 2023. PMID: 37270808 Free PMC article.
Replacement of Y158 with 3-fluoroTyr (3-FY) and 3,5-difluoroTyr (3,5-F(2)Y) has no effect on k(cat)(app)/K(M)(app) nor on the binding of inhibitors to the open form of the enzyme (K(i)(app)), whereas both k(cat)(app)/K(M)(app) and K(i)(app) are altered by seven-fold …
Replacement of Y158 with 3-fluoroTyr (3-FY) and 3,5-difluoroTyr (3,5-F(2)Y) has no effect on k(cat)(app)/K(M)(app) nor on the binding …
Role of ESAT-6 in pathogenicity of Beijing and non-Beijing Mycobacterium tuberculosis isolates.
Mahghani GA, Kargar M, Ghaemi EA, Kafilzadeh F, Davoodi H. Mahghani GA, et al. Microb Pathog. 2022 Jan;162:105366. doi: 10.1016/j.micpath.2021.105366. Epub 2021 Dec 27. Microb Pathog. 2022. PMID: 34968645
MATERIALS & METHODS: Among 64 nonrepetitive, culture-positive M.tuberculosis, DNA extraction of 24 and 40 pure confirmed Beijing and non-Beijing isolates was accompanied by the boiling method. esat-6 gene PCR amplification and their sequencing were carried out by speci …
MATERIALS & METHODS: Among 64 nonrepetitive, culture-positive M.tuberculosis, DNA extraction of 24 and 40 pure confirmed Beijing …
Adsorptive removal of azithromycin from aqueous solutions using raw and saponin-modified nano diatomite.
Davoodi S, Dahrazma B, Goudarzi N, Gorji HG. Davoodi S, et al. Water Sci Technol. 2019 Sep;80(5):939-949. doi: 10.2166/wst.2019.337. Water Sci Technol. 2019. PMID: 31746801
It was shown that the specific surface area of R-ND was 119.5 m(2)/g, 14-fold higher than that for raw diatomite, and for M-ND it was 90.1 m(2)/g. ...The maximum adsorption capacity of R-ND and M-ND in the removal of azithromycin was 68 and 91.7 mg/g, …
It was shown that the specific surface area of R-ND was 119.5 m(2)/g, 14-fold higher than that for raw diatomite, and for M-ND …
Replacement of the ectodomains of the hemagglutinin-neuraminidase and fusion glycoproteins of recombinant parainfluenza virus type 3 (PIV3) with their counterparts from PIV2 yields attenuated PIV2 vaccine candidates.
Tao T, Skiadopoulos MH, Davoodi F, Riggs JM, Collins PL, Murphy BR. Tao T, et al. J Virol. 2000 Jul;74(14):6448-58. doi: 10.1128/jvi.74.14.6448-6458.2000. J Virol. 2000. PMID: 10864657 Free PMC article.
Tao et al., J. Virol. 72:2955-2961, 1998; M. H. Skiadopoulos et al., Vaccine 18:503-510, 1999). However, using the same strategy, we failed to recover recombinant chimeric PIV3-PIV2 isolate carrying the full-length PIV2 glycoproteins in a wild-type PIV3 backbone. .. …
Tao et al., J. Virol. 72:2955-2961, 1998; M. H. Skiadopoulos et al., Vaccine 18:503-510, 1999). However, using the same strate …
ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines.
Dariushnejad H, Zarghami N, Rahmati M, Ghasemali S, Sadeghi Z, Davoodi Z, Jafari Tekab H, Gandomkar Ghalhar M. Dariushnejad H, et al. Adv Pharm Bull. 2014;4(2):185-9. doi: 10.5681/apb.2014.027. Epub 2013 Dec 24. Adv Pharm Bull. 2014. PMID: 24511483 Free PMC article.
RESULTS: IC50 values of DNR and ABT-737 were 2.52 and 0.59 M for HL-60 cells line and 1.31 and 0.80 M for U937 cell line at 24 h, respectively. ...
RESULTS: IC50 values of DNR and ABT-737 were 2.52 and 0.59 M for HL-60 cells line and 1.31 and 0.80 M for U937 cell line at 24 …
Sodium bicarbonate plus isotonic saline versus saline for prevention of contrast-induced nephropathy in patients undergoing coronary angiography: a randomized controlled trial.
Vasheghani-Farahani A, Sadigh G, Kassaian SE, Khatami SM, Fotouhi A, Razavi SA, Mansournia MA, Yamini-Sharif A, Amirzadegan A, Salarifar M, Sadeghian S, Davoodi G, Borumand MA, Esfehani FA, Darabian S. Vasheghani-Farahani A, et al. Am J Kidney Dis. 2009 Oct;54(4):610-8. doi: 10.1053/j.ajkd.2009.05.016. Epub 2009 Jul 19. Am J Kidney Dis. 2009. PMID: 19619921 Clinical Trial.
INTERVENTION: Study participants were randomly assigned to receive either 75 mL of 8.4% sodium bicarbonate added to 1 L of isotonic saline (n = 135) or isotonic saline alone (n = 130) as a bolus of 3 mL/kg for 1 hour before contrast injection, followed by an infusion of 1 mL/kg/ …
INTERVENTION: Study participants were randomly assigned to receive either 75 mL of 8.4% sodium bicarbonate added to 1 L of isotonic saline ( …
Crystal engineering of an adenine-decavanadate molecular device towards label-free chemical sensing and biological screening.
Sedghiniya S, Soleimannejad J, Jahani Z, Davoodi J, Janczak J. Sedghiniya S, et al. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2020 Feb 1;76(Pt 1):85-92. doi: 10.1107/S2052520619016196. Epub 2020 Jan 24. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2020. PMID: 32831244
In this work, the [AdH](6)[V(10)O(28)].4(H(2)O) (1) supramolecular structure is introduced using adenine and decavanadate moieties that allow probing of selectivity to specific nucleic acid binding events by optical changes. ...It was found that compound (1) is cell permea …
In this work, the [AdH](6)[V(10)O(28)].4(H(2)O) (1) supramolecular structure is introduced using adenine and decavanadate moieties th …
Mitigation of hyperglycemia-induced leydig cell dysfunction by gut derived indol 3- propionic acid: Targeting apoptosis, endoplasmic reticulum stress response and steroidogenesis.
Jalili C, Zamir Nasta T, Makalani F, Davoodi E, Tabandeh MR. Jalili C, et al. Reprod Toxicol. 2025 Oct;137:108987. doi: 10.1016/j.reprotox.2025.108987. Epub 2025 Jul 6. Reprod Toxicol. 2025. PMID: 40628365
TM3 mouse Leydig cells were cultured in DMEM/F12 medium containing low (5 mM) and high (30 mM) glucose concentrations in the presence of 10 and 20 M of IPA for 24 h. Cell viability was assessed by MTT method. The expression of steroidogenesis associated genes 3beta- …
TM3 mouse Leydig cells were cultured in DMEM/F12 medium containing low (5 mM) and high (30 mM) glucose concentrations in the presence of 10 …
Modulation of vitamin D receptor and estrogen receptor by 1,25(OH)2-vitamin D3 in T-47D human breast cancer cells.
Davoodi F, Brenner RV, Evans SR, Schumaker LM, Shabahang M, Nauta RJ, Buras RR. Davoodi F, et al. J Steroid Biochem Mol Biol. 1995 Aug;54(3-4):147-53. doi: 10.1016/0960-0760(95)00128-m. J Steroid Biochem Mol Biol. 1995. PMID: 7662588 Free article.

Significant VDR up-regulation, as measured by hormone binding assays, occurred with pre-incubations with 10(-9)M through 10(-6)M 1,25(OH)2-vitamin D3 (P < 0.05). A 7-fold VDR up-regulation with 10(-8)M 1,25(OH)2-vitamin D3 occurred at 4 h treatment

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Significant VDR up-regulation, as measured by hormone binding assays, occurred with pre-incubations with 10(-9)M through 10(-6)M …